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- W2988409544 abstract "Abstract This study investigated the effects of xyloglucan (XG) on gut microbiota, bile acid metabolism, and liver injury in mice fed with high-fat diet (HFD). Thirty male ICR/KM mice were randomly divided into three groups, as follows: control group (10% fat energy); high-fat group (60% fat energy); and XG group (8% XG supplemented in a high-fat diet). The mice were sacrificed after 8 weeks, and samples were collected. XG reduced the body weight, serum, and liver lipids of high-fat mice and gut-liver axis circulation bile acid level. Liver damage and gut disorders caused by HFD were relieved after XG supplementation. The intestinal bile acid metabolism farnesoid X receptor-small heterodimer partner (FXR-SHP) pathway was up-regulated by XG. XG reduced liver damage and obesity by regulating gut microbiota to up-regulate the intestinal bile acid metabolism pathways of HFD-fed mice." @default.
- W2988409544 created "2019-11-22" @default.
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- W2988409544 date "2020-01-01" @default.
- W2988409544 modified "2023-09-30" @default.
- W2988409544 title "Xyloglucan affects gut-liver circulating bile acid metabolism to improve liver damage in mice fed with high-fat diet" @default.
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- W2988409544 doi "https://doi.org/10.1016/j.jff.2019.103651" @default.
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