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- W2988529192 abstract "### What you need to know Children and adolescents with epilepsy are medically managed by paediatricians with expertise in the condition, but non-specialist doctors can also help these young people live a fuller life. In this update we focus on important issues that are sometimes misunderstood, particularly those with little published guidance or where new evidence or guidance has emerged. The advice applies mainly to children with common epilepsies attending mainstream schools. Children with complex epilepsy require specialist guidance.Official guidance and discussions on social media are conservative on the question of switching1 between different products, while prescribers are encouraged to use cheaper generic drug treatments. On balance, we advise consistency in prescribing (in the UK it not uncommon for the pharmacy to have different formulations every time the patient goes to renew the prescription) because comparative bioavailability data are incomplete for every anti-epileptic drug.2 Only the 2016 EQUIGEN study3 showed that switching between branded and generic lamotrigine was safe. Furthermore, the different names, packaging, and appearance of alternative products may cause confusion, anxiety, or occasionally non-adherence when prescriptions are refilled.Table 1 lists anti-epileptic drugs stratified by risk of switching, according to their therapeutic index and release characteristics.4View this table:Table 1 Risk categories for switching between generic and branded formulations of anti-epileptic drugs4Management of a missed …" @default.
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- W2988529192 date "2019-11-11" @default.
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- W2988529192 title "Practical aspects of childhood epilepsy" @default.
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- W2988529192 doi "https://doi.org/10.1136/bmj.l6096" @default.
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