Matches in SemOpenAlex for { <https://semopenalex.org/work/W2988576576> ?p ?o ?g. }
- W2988576576 endingPage "1775" @default.
- W2988576576 startingPage "1775" @default.
- W2988576576 abstract "Despite advances in diagnostic tools and therapeutic options, treatment resistance remains a challenge for many cancer patients. Recent studies have found evidence that autophagy, a cellular pathway that delivers cytoplasmic components to lysosomes for degradation and recycling, contributes to treatment resistance in different cancer types. A role for autophagy in resistance to chemotherapies and targeted therapies has been described based largely on associations with various signaling pathways, including MAPK and PI3K/AKT signaling. However, our current understanding of the molecular mechanisms underlying the role of autophagy in facilitating treatment resistance remains limited. Here we provide a comprehensive summary of the evidence linking autophagy to major signaling pathways in the context of treatment resistance and tumor progression, and then highlight recently emerged molecular mechanisms underlying autophagy and the p62/KEAP1/NRF2 and FOXO3A/PUMA axes in chemoresistance." @default.
- W2988576576 created "2019-11-22" @default.
- W2988576576 creator A5021622702 @default.
- W2988576576 creator A5086218786 @default.
- W2988576576 date "2019-11-11" @default.
- W2988576576 modified "2023-10-15" @default.
- W2988576576 title "Molecular Mechanisms Underlying Autophagy-Mediated Treatment Resistance in Cancer" @default.
- W2988576576 cites W1490956705 @default.
- W2988576576 cites W1495956204 @default.
- W2988576576 cites W1523693806 @default.
- W2988576576 cites W1526922376 @default.
- W2988576576 cites W1545541064 @default.
- W2988576576 cites W1547736903 @default.
- W2988576576 cites W1572875808 @default.
- W2988576576 cites W1585268103 @default.
- W2988576576 cites W1675481208 @default.
- W2988576576 cites W1728633607 @default.
- W2988576576 cites W1818313483 @default.
- W2988576576 cites W1845237317 @default.
- W2988576576 cites W1852800533 @default.
- W2988576576 cites W1864635191 @default.
- W2988576576 cites W1877976446 @default.
- W2988576576 cites W1900103347 @default.
- W2988576576 cites W1918457714 @default.
- W2988576576 cites W1936571436 @default.
- W2988576576 cites W1951741034 @default.
- W2988576576 cites W1964272901 @default.
- W2988576576 cites W1966092834 @default.
- W2988576576 cites W1969476452 @default.
- W2988576576 cites W1972612572 @default.
- W2988576576 cites W1974600881 @default.
- W2988576576 cites W1976232839 @default.
- W2988576576 cites W1976246361 @default.
- W2988576576 cites W1977079962 @default.
- W2988576576 cites W1977755045 @default.
- W2988576576 cites W1978520932 @default.
- W2988576576 cites W1980670479 @default.
- W2988576576 cites W1981789201 @default.
- W2988576576 cites W1983275934 @default.
- W2988576576 cites W1985820389 @default.
- W2988576576 cites W1987566410 @default.
- W2988576576 cites W1988105205 @default.
- W2988576576 cites W1991050083 @default.
- W2988576576 cites W1991398927 @default.
- W2988576576 cites W1991721604 @default.
- W2988576576 cites W1995229256 @default.
- W2988576576 cites W1995508516 @default.
- W2988576576 cites W1995922314 @default.
- W2988576576 cites W1996299534 @default.
- W2988576576 cites W1996936702 @default.
- W2988576576 cites W1997347278 @default.
- W2988576576 cites W1999328539 @default.
- W2988576576 cites W1999860107 @default.
- W2988576576 cites W2001314904 @default.
- W2988576576 cites W2005142336 @default.
- W2988576576 cites W2005734249 @default.
- W2988576576 cites W2006483529 @default.
- W2988576576 cites W2006892443 @default.
- W2988576576 cites W2006937936 @default.
- W2988576576 cites W2008713443 @default.
- W2988576576 cites W2009101631 @default.
- W2988576576 cites W2009685214 @default.
- W2988576576 cites W2012204604 @default.
- W2988576576 cites W2013383578 @default.
- W2988576576 cites W2013544053 @default.
- W2988576576 cites W2013941971 @default.
- W2988576576 cites W2020337923 @default.
- W2988576576 cites W2020632804 @default.
- W2988576576 cites W2024085992 @default.
- W2988576576 cites W2024899639 @default.
- W2988576576 cites W2025137213 @default.
- W2988576576 cites W2025291821 @default.
- W2988576576 cites W2025523323 @default.
- W2988576576 cites W2026198376 @default.
- W2988576576 cites W2027216014 @default.
- W2988576576 cites W2032109805 @default.
- W2988576576 cites W2033433904 @default.
- W2988576576 cites W2033843689 @default.
- W2988576576 cites W2036204029 @default.
- W2988576576 cites W2040875703 @default.
- W2988576576 cites W2042377836 @default.
- W2988576576 cites W2042422855 @default.
- W2988576576 cites W2043682963 @default.
- W2988576576 cites W2045319943 @default.
- W2988576576 cites W2048244283 @default.
- W2988576576 cites W2048571348 @default.
- W2988576576 cites W2052618262 @default.
- W2988576576 cites W2054239953 @default.
- W2988576576 cites W2054318449 @default.
- W2988576576 cites W2055107833 @default.
- W2988576576 cites W2055807959 @default.
- W2988576576 cites W2058283739 @default.
- W2988576576 cites W2061219331 @default.
- W2988576576 cites W2061664912 @default.
- W2988576576 cites W2061825330 @default.
- W2988576576 cites W2062466754 @default.
- W2988576576 cites W2063701247 @default.
- W2988576576 cites W2066648049 @default.