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- W2988577029 abstract "Role of GADD34, a protein that is induced following cellular stress, in HIV-1 replication was investigated. GADD34 was induced during the late phase of HIV-1 infection. siRNA-knockdown of GADD34 stimulated whereas overexpression of GADD34 inhibited HIV-1 replication. GADD34 N-terminal ER-binding-helix amino acid region 1–192 alone was found to be sufficient for the inhibition of HIV-1 replication whereas protein-phosphatase -1-binding domain and eIF-2α-phosphatase activity of GADD34 were not crucial for anti-HIV-1 activity. GADD34 did not alter the HIV-1 RNA levels but reduced the viral protein expression suggesting that GADD34 interferes in HIV protein synthesis. Studies on the effect of HIV-1-5′-UTR and its mutants on a human promoter-driven luciferase expression indicated that GADD34-inhibition was mediated by 5′-UTR/TAR RNA, probably by modulating TAR RNA structure. In summary, our data support a novel function of GADD34 as a putative anti-HIV-1 restriction factor." @default.
- W2988577029 created "2019-11-22" @default.
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- W2988577029 date "2020-01-01" @default.
- W2988577029 modified "2023-09-29" @default.
- W2988577029 title "GADD34 attenuates HIV-1 replication by viral 5′-UTR TAR RNA-mediated translational inhibition" @default.
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- W2988577029 doi "https://doi.org/10.1016/j.virol.2019.11.010" @default.
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