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- W2988599334 endingPage "109912" @default.
- W2988599334 startingPage "109912" @default.
- W2988599334 abstract "Synthetic progestins are emerging contaminants of the aquatic environment with endocrine disrupting potential. The main aim of the present study was to investigate the effects of the synthetic progestins gestodene, and drospirenone on sex differentiation in common carp (Cyprinus carpio) by histological analysis. To gain insights into the mechanisms behind the observations from the in vivo experiment on sex differentiation, we analyzed expression of genes involved in hypothalamus-pituitary-gonad (HPG) and hypothalamus-pituitary-thyroid (HPT) axes, histology of hepatopancreas, and in vitro bioassays. Carp were continuously exposed to concentrations of 2 ng/L of single progestins (gestodene or drospirenone) or to their mixture at concentration 2 ng/L of each. The exposure started 24 h after fertilization of eggs and concluded 160 days post-hatching. Our results showed that exposure of common carp to a binary mixture of drospirenone and gestodene caused increased incidence of intersex (32%) when compared to clean water and solvent control groups (both 3%). Intersex most probably was induced by a combination of multiple modes of action of the studied substances, namely anti-gonadotropic activity, interference with androgen receptor, and potentially also with HPT axis or estrogen receptor." @default.
- W2988599334 created "2019-11-22" @default.
- W2988599334 creator A5000077758 @default.
- W2988599334 creator A5030473803 @default.
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- W2988599334 creator A5044227579 @default.
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- W2988599334 creator A5068262905 @default.
- W2988599334 creator A5068965466 @default.
- W2988599334 creator A5070348265 @default.
- W2988599334 date "2020-01-01" @default.
- W2988599334 modified "2023-10-18" @default.
- W2988599334 title "Chronic simultaneous exposure of common carp (Cyprinus carpio) from embryonic to juvenile stage to drospirenone and gestodene at low ng/L level caused intersex" @default.
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