Matches in SemOpenAlex for { <https://semopenalex.org/work/W2988607739> ?p ?o ?g. }
- W2988607739 endingPage "5680" @default.
- W2988607739 startingPage "5680" @default.
- W2988607739 abstract "The need for more effective therapies of chronic and acute diseases has led to the attempts of developing more adequate and less invasive treatment methods. Regenerative medicine relies mainly on the therapeutic potential of stem cells. Mesenchymal stem cells (MSCs), due to their immunosuppressive properties and tissue repair abilities, seem to be an ideal tool for cell-based therapies. Taking into account all available sources of MSCs, perinatal tissues become an attractive source of allogeneic MSCs. The allogeneic MSCs provide “off-the-shelf” cellular therapy, however, their allogenicity may be viewed as a limitation for their use. Moreover, some evidence suggests that MSCs are not as immune-privileged as it was previously reported. Therefore, understanding their interactions with the recipient’s immune system is crucial for their successful clinical application. In this review, we discuss both autologous and allogeneic application of MSCs, focusing on current approaches to allogeneic MSCs therapies, with a particular interest in the role of human leukocyte antigens (HLA) and HLA-matching in allogeneic MSCs transplantation. Importantly, the evidence from the currently completed and ongoing clinical trials demonstrates that allogeneic MSCs transplantation is safe and seems to cause no major side-effects to the patient. These findings strongly support the case for MSCs efficacy in treatment of a variety of diseases and their use as an “off-the-shelf” medical product." @default.
- W2988607739 created "2019-11-22" @default.
- W2988607739 creator A5041196934 @default.
- W2988607739 creator A5062048908 @default.
- W2988607739 creator A5064183255 @default.
- W2988607739 creator A5064542717 @default.
- W2988607739 creator A5075602382 @default.
- W2988607739 creator A5076659659 @default.
- W2988607739 date "2019-11-13" @default.
- W2988607739 modified "2023-09-27" @default.
- W2988607739 title "The Importance of HLA Assessment in “Off-the-Shelf” Allogeneic Mesenchymal Stem Cells Based-Therapies" @default.
- W2988607739 cites W1490068550 @default.
- W2988607739 cites W1597881733 @default.
- W2988607739 cites W1619770660 @default.
- W2988607739 cites W1686409300 @default.
- W2988607739 cites W1796142965 @default.
- W2988607739 cites W1818584021 @default.
- W2988607739 cites W1832274221 @default.
- W2988607739 cites W1918719004 @default.
- W2988607739 cites W1965781909 @default.
- W2988607739 cites W1967222268 @default.
- W2988607739 cites W1967527437 @default.
- W2988607739 cites W1967612002 @default.
- W2988607739 cites W1968133243 @default.
- W2988607739 cites W1969854175 @default.
- W2988607739 cites W1969998172 @default.
- W2988607739 cites W1970924670 @default.
- W2988607739 cites W1971789451 @default.
- W2988607739 cites W1973011259 @default.
- W2988607739 cites W1973863581 @default.
- W2988607739 cites W1981359573 @default.
- W2988607739 cites W1982274668 @default.
- W2988607739 cites W1982916645 @default.
- W2988607739 cites W1985703183 @default.
- W2988607739 cites W1988217196 @default.
- W2988607739 cites W1988940450 @default.
- W2988607739 cites W1991328368 @default.
- W2988607739 cites W1995499825 @default.
- W2988607739 cites W1998883576 @default.
- W2988607739 cites W1998941039 @default.
- W2988607739 cites W2003996125 @default.
- W2988607739 cites W2005943573 @default.
- W2988607739 cites W2006911274 @default.
- W2988607739 cites W2012132345 @default.
- W2988607739 cites W2012309077 @default.
- W2988607739 cites W2014603632 @default.
- W2988607739 cites W2014917490 @default.
- W2988607739 cites W2019495971 @default.
- W2988607739 cites W2024326908 @default.
- W2988607739 cites W2025371271 @default.
- W2988607739 cites W2025504449 @default.
- W2988607739 cites W2026554298 @default.
- W2988607739 cites W2028046200 @default.
- W2988607739 cites W2028089243 @default.
- W2988607739 cites W2034336542 @default.
- W2988607739 cites W2035040282 @default.
- W2988607739 cites W2035456945 @default.
- W2988607739 cites W2035976926 @default.
- W2988607739 cites W2036689013 @default.
- W2988607739 cites W2038331701 @default.
- W2988607739 cites W2038399651 @default.
- W2988607739 cites W2038760332 @default.
- W2988607739 cites W2039092109 @default.
- W2988607739 cites W2039665103 @default.
- W2988607739 cites W2039751388 @default.
- W2988607739 cites W2043538135 @default.
- W2988607739 cites W2044285352 @default.
- W2988607739 cites W2044695442 @default.
- W2988607739 cites W2047003816 @default.
- W2988607739 cites W2048308706 @default.
- W2988607739 cites W2048484529 @default.
- W2988607739 cites W2049292651 @default.
- W2988607739 cites W2050018625 @default.
- W2988607739 cites W2050321396 @default.
- W2988607739 cites W2051285351 @default.
- W2988607739 cites W2054238236 @default.
- W2988607739 cites W2054248603 @default.
- W2988607739 cites W2054973241 @default.
- W2988607739 cites W2055689262 @default.
- W2988607739 cites W2056667831 @default.
- W2988607739 cites W2058446860 @default.
- W2988607739 cites W2060657837 @default.
- W2988607739 cites W2062042885 @default.
- W2988607739 cites W2063598213 @default.
- W2988607739 cites W2071833071 @default.
- W2988607739 cites W2071904806 @default.
- W2988607739 cites W2074127181 @default.
- W2988607739 cites W2075510710 @default.
- W2988607739 cites W2077082217 @default.
- W2988607739 cites W2077694466 @default.
- W2988607739 cites W2078171389 @default.
- W2988607739 cites W2078916311 @default.
- W2988607739 cites W2080539468 @default.
- W2988607739 cites W2083154922 @default.
- W2988607739 cites W2088964957 @default.
- W2988607739 cites W2089300804 @default.
- W2988607739 cites W2090864977 @default.
- W2988607739 cites W2102418967 @default.