FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2988710052> ?p ?o ?g. }

• W2988710052 endingPage "108869" @default.
• W2988710052 startingPage "108869" @default.
• W2988710052 abstract "Spermatogenic dysfunction is one of the major secondary complications of male diabetes. Salidroside (SAL) is the important active ingredients isolated from Herba Cistanche, which exhibits numerous pharmacological activities such as antioxidant, anti-diabetic, and anti-inflammatory effects. The present study was designed to determine whether SAL contributes to the recovery from spermatogenic dysfunction in streptozotocin (STZ) induced type-1 diabetic mice. SAL (25, 50, or 100 mg/kg) and Clomiphene citrate (CC, 5 mg/kg) were orally administered to male type-1 diabetic mice for 10 weeks. Testis tissues were collected for histopathological and biochemical analysis. Moreover, reproductive organ weight, sperm parameters, and testicular cell DNA damage were estimated. The results revealed that SAL significantly improved the weight of the reproductive organs, sperm parameters and testicular morphology to different degrees in type-1 diabetic mice. Furthermore, reactive oxygen species (ROS) and malondialdehyde (MDA) levels were significantly reduced, and the activities of superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH), markedly increased in the testicular tissue after SAL treatment. In addition, our data also showed a marked downregulation the fluorescence expressions of p38 MAPK phosphorylation and upregulation the protein expressions of ZO-1, Occludin, Claudin-11 and N-cadherin after SAL administration (100 mg/kg) compared with the type-1 diabetic group. In conclusion, these results demonstrated that SAL exerts protective effects on type-1 diabetes-induced male spermatogenic dysfunction, which is likely mediated by inhibiting oxidative stress-mediated blood testis barrier damage." @default.
• W2988710052 created "2019-11-22" @default.
• W2988710052 creator A5024180269 @default.
• W2988710052 creator A5025726576 @default.
• W2988710052 creator A5051459499 @default.
• W2988710052 creator A5052894175 @default.
• W2988710052 creator A5061832044 @default.
• W2988710052 creator A5070900536 @default.
• W2988710052 creator A5075768357 @default.
• W2988710052 creator A5083300951 @default.
• W2988710052 creator A5089741453 @default.
• W2988710052 creator A5091729113 @default.
• W2988710052 date "2020-01-01" @default.
• W2988710052 modified "2023-10-06" @default.
• W2988710052 title "Protective effects of Salidroside on spermatogenesis in streptozotocin induced type-1 diabetic male mice by inhibiting oxidative stress mediated blood-testis barrier damage" @default.
• W2988710052 cites W1517625476 @default.
• W2988710052 cites W1849077372 @default.
• W2988710052 cites W1892219175 @default.
• W2988710052 cites W1972502627 @default.
• W2988710052 cites W1981862111 @default.
• W2988710052 cites W1992977856 @default.
• W2988710052 cites W2010173332 @default.
• W2988710052 cites W2013411735 @default.
• W2988710052 cites W2018657996 @default.
• W2988710052 cites W2019750418 @default.
• W2988710052 cites W2029804435 @default.
• W2988710052 cites W2042342900 @default.
• W2988710052 cites W2057769056 @default.
• W2988710052 cites W2065221771 @default.
• W2988710052 cites W2069644908 @default.
• W2988710052 cites W2074934613 @default.
• W2988710052 cites W2077315330 @default.
• W2988710052 cites W2114291584 @default.
• W2988710052 cites W2119276562 @default.
• W2988710052 cites W2124333585 @default.
• W2988710052 cites W2153598618 @default.
• W2988710052 cites W2180177645 @default.
• W2988710052 cites W2284443530 @default.
• W2988710052 cites W2289740209 @default.
• W2988710052 cites W2474176246 @default.
• W2988710052 cites W2507302429 @default.
• W2988710052 cites W2514112501 @default.
• W2988710052 cites W2517056952 @default.
• W2988710052 cites W2539784013 @default.
• W2988710052 cites W2550583748 @default.
• W2988710052 cites W2587002615 @default.
• W2988710052 cites W2587753558 @default.
• W2988710052 cites W2606650835 @default.
• W2988710052 cites W2745134991 @default.
• W2988710052 cites W2746401070 @default.
• W2988710052 cites W2752794913 @default.
• W2988710052 cites W2763127917 @default.
• W2988710052 cites W2767825002 @default.
• W2988710052 cites W2769665411 @default.
• W2988710052 cites W2780460002 @default.
• W2988710052 cites W2791011305 @default.
• W2988710052 cites W2793413416 @default.
• W2988710052 cites W2799856742 @default.
• W2988710052 cites W2803981780 @default.
• W2988710052 cites W2810666532 @default.
• W2988710052 cites W2896360405 @default.
• W2988710052 cites W2903857071 @default.
• W2988710052 cites W2910128258 @default.
• W2988710052 cites W2947783949 @default.
• W2988710052 cites W2948986033 @default.
• W2988710052 cites W833956060 @default.
• W2988710052 doi "https://doi.org/10.1016/j.cbi.2019.108869" @default.
• W2988710052 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31682803" @default.
• W2988710052 hasPublicationYear "2020" @default.
• W2988710052 type Work @default.
• W2988710052 sameAs 2988710052 @default.
• W2988710052 citedByCount "20" @default.
• W2988710052 countsByYear W29887100522020 @default.
• W2988710052 countsByYear W29887100522021 @default.
• W2988710052 countsByYear W29887100522022 @default.
• W2988710052 countsByYear W29887100522023 @default.
• W2988710052 crossrefType "journal-article" @default.
• W2988710052 hasAuthorship W2988710052A5024180269 @default.
• W2988710052 hasAuthorship W2988710052A5025726576 @default.
• W2988710052 hasAuthorship W2988710052A5051459499 @default.
• W2988710052 hasAuthorship W2988710052A5052894175 @default.
• W2988710052 hasAuthorship W2988710052A5061832044 @default.
• W2988710052 hasAuthorship W2988710052A5070900536 @default.
• W2988710052 hasAuthorship W2988710052A5075768357 @default.
• W2988710052 hasAuthorship W2988710052A5083300951 @default.
• W2988710052 hasAuthorship W2988710052A5089741453 @default.
• W2988710052 hasAuthorship W2988710052A5091729113 @default.
• W2988710052 hasConcept C123765429 @default.
• W2988710052 hasConcept C126322002 @default.
• W2988710052 hasConcept C134018914 @default.
• W2988710052 hasConcept C16685009 @default.
• W2988710052 hasConcept C2775838275 @default.
• W2988710052 hasConcept C2776151105 @default.
• W2988710052 hasConcept C2778401633 @default.
• W2988710052 hasConcept C2779280383 @default.
• W2988710052 hasConcept C2779526882 @default.
• W2988710052 hasConcept C2781087480 @default.
• W2988710052 hasConcept C48349386 @default.

• next