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• W2988752695 abstract "Purpose To develop a 3D sequence for T 1ρ relaxation mapping using radial volumetric encoding (3D‐T 1ρ ‐RAVE) and to evaluate the multi relaxation components in the liver of healthy controls and chronic liver disease (CLD) patients. Methods Fat saturation and T 1ρ preparation modules were followed by a train of gradient‐echo acquisitions and T 1 restoration delay. The series of T 1ρ ‐weighted images were fitted using mono‐exponential, bi‐exponential, and stretched‐exponential models. The repeatability and reproducibility of the proposed technique were evaluated on National Institute of Standards and Technology phantom by calculating the coefficient of variation between test‐retest scans on the same scanner and between two different 3T scanners, respectively. Mann‐Whitney U‐test was performed to assess differences in T 1ρ components among patients ( n = 3) and a control group ( n = 10). Results The phantom study showed an error of 8.9% and 11.5% in mono T 2 relaxation time measurement relative to the reference on 2 different scanners. The coefficient of variation for test‐retest scans performed on the same scanner was 5.7% and 2.4% for scans performed on 2 scanners. The comparison between healthy controls and CLD patients showed a significant difference ( P < .05) in mono relaxation time ( P = .002), stretched‐exponential relaxation parameter ( P = .04). The Akaike information criteria C criterion showed 2.53 ± 0.9% (2.3 ± 0.3% for CLD) of the voxels are bi‐exponential while in 65.3 ± 5.8% (81.2 ± 0.06% for CLD) of the liver voxels, the stretched‐exponential model was preferred. Conclusion The 3D‐T 1ρ ‐RAVE sequence allows volumetric, multicomponent T 1ρ assessment of the liver during free breathing and can distinguish between healthy volunteers and CLD patients." @default.
• W2988752695 created "2019-11-22" @default.
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• W2988752695 date "2019-11-14" @default.
• W2988752695 modified "2023-10-17" @default.
• W2988752695 title "Volumetric multicomponent T_1ρ relaxation mapping of the human liver under free breathing at 3T" @default.
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• W2988752695 doi "https://doi.org/10.1002/mrm.28061" @default.
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