FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2988761623> ?p ?o ?g. }

• W2988761623 endingPage "2195" @default.
• W2988761623 startingPage "2195" @default.
• W2988761623 abstract "Introduction. The diagnosis of multiple myeloma (MM) is often made in elderly individuals (median age at diagnosis 69 years) with over a third of patients exceeding 75 years of age. Many elderly patients are frequently excluded from clinical trials because of predefined upper age limit of 65 years limiting accessibility to autologous stem cell transplant (ASCT) for a large proportion of MM patients. Based on limited multicenter studies and randomized clinical trials in this population, we used the National Cancer Database (NCDB) to assess the outcomes of ASCT in MM patients older than 65 years of age. Methods. We queried the NCDB for patients with MM diagnosed between 2004 -2015 treated with ASCT as frontline therapy, yielding a final cohort of 9,383 patients. Multivariable logistic regression was used to determine the likelihood of receiving ASCT. Overall survival (OS) was calculated from the date of diagnosis to the date of last contact or death using Kaplan Meier methodology. Adjusted hazard ratios (HR) and 95% confidence interval (CI) are reported, with α=0.05 used to indicate statistical significance. Results. The median age was 67.0 (range: 19-90). The majority of patients were older than 65 (58.5%), male (54.7%), Caucasian (75.6%), had government insurance (88%)and had a Charlson-Deyo Comorbidity score (CDCS) of 0 (75.5%). In addition to older age, insurance status, low annual income higher CDCS were associated with lower chances of receiving ASCT (Table 1). Patients in Urban areas (OR 1.377, CI 95% 1.286-1.475), and patients in Academic/Research Centers (OR 4.379 were CI 95%, 3.852-4.978) were more likely to receive ASCT. In patients younger than 65-years of age rate of ASCT was 7.0% in 2004 and increased to 16.7% in 2015. The annual rate of ASCT in patients older than 65-years of age was 1.1% in 2004 and increased to 4.7% in 2015. The multivariable cox proportional hazards of death in patients receiving ASCT was associated with improved survival (HR 0.492, CI 95% 0.473-0.512). Age (>65 years old HR 1.184, 95% CI 1.053-1.331), insurance status (uninsured HR 1.361, CI 95% 1.302-1.422, Medicaid HR 1.365, 95% CI 1.318-1.414, Medicare HR 1.271, 95% CI 1.244-1.299) and higher comorbidity score were associated with worse survival (Table 2). Median survival in patients younger than 65-years old receiving ASCT was 102.6 month versus 66.6 months in patients not receiving ASCT (HR 0.596, 95% CI 0.568-0.624) (Figure 1). Median survival in patients older than 65 years old and not receiving ASCT was 86.3 months versus 28.4 months in patients not receiving ASCT (HR 0.344, 95% CI 0.0320-0.371). Conclusions. The findings of the present study demonstrate decreased utilization of ASCT in older patients with MM, despite significant survival benefit of such therapy. Other factors associated with decreased likelihood of ASCT are such as insurance status and annual income unfold existing disparities in patients with MM receiving ASCT. Disclosures No relevant conflicts of interest to declare." @default.
• W2988761623 created "2019-11-22" @default.
• W2988761623 creator A5000701261 @default.
• W2988761623 creator A5008782678 @default.
• W2988761623 creator A5013162454 @default.
• W2988761623 creator A5028159293 @default.
• W2988761623 creator A5037050016 @default.
• W2988761623 creator A5060606996 @default.
• W2988761623 creator A5078734526 @default.
• W2988761623 creator A5088147072 @default.
• W2988761623 date "2019-11-13" @default.
• W2988761623 modified "2023-09-27" @default.
• W2988761623 title "Autologous Stem Cell Transplantation in Multiple Myeloma Patients Older Than 65 Year-Old, 12-Years Analysis of National Cancer Database" @default.
• W2988761623 doi "https://doi.org/10.1182/blood-2019-127879" @default.
• W2988761623 hasPublicationYear "2019" @default.
• W2988761623 type Work @default.
• W2988761623 sameAs 2988761623 @default.
• W2988761623 citedByCount "0" @default.
• W2988761623 crossrefType "journal-article" @default.
• W2988761623 hasAuthorship W2988761623A5000701261 @default.
• W2988761623 hasAuthorship W2988761623A5008782678 @default.
• W2988761623 hasAuthorship W2988761623A5013162454 @default.
• W2988761623 hasAuthorship W2988761623A5028159293 @default.
• W2988761623 hasAuthorship W2988761623A5037050016 @default.
• W2988761623 hasAuthorship W2988761623A5060606996 @default.
• W2988761623 hasAuthorship W2988761623A5078734526 @default.
• W2988761623 hasAuthorship W2988761623A5088147072 @default.
• W2988761623 hasBestOaLocation W29887616231 @default.
• W2988761623 hasConcept C121608353 @default.
• W2988761623 hasConcept C126322002 @default.
• W2988761623 hasConcept C141071460 @default.
• W2988761623 hasConcept C207103383 @default.
• W2988761623 hasConcept C2776364478 @default.
• W2988761623 hasConcept C2779050716 @default.
• W2988761623 hasConcept C2908647359 @default.
• W2988761623 hasConcept C2911091166 @default.
• W2988761623 hasConcept C44249647 @default.
• W2988761623 hasConcept C71924100 @default.
• W2988761623 hasConcept C72563966 @default.
• W2988761623 hasConcept C99454951 @default.
• W2988761623 hasConceptScore W2988761623C121608353 @default.
• W2988761623 hasConceptScore W2988761623C126322002 @default.
• W2988761623 hasConceptScore W2988761623C141071460 @default.
• W2988761623 hasConceptScore W2988761623C207103383 @default.
• W2988761623 hasConceptScore W2988761623C2776364478 @default.
• W2988761623 hasConceptScore W2988761623C2779050716 @default.
• W2988761623 hasConceptScore W2988761623C2908647359 @default.
• W2988761623 hasConceptScore W2988761623C2911091166 @default.
• W2988761623 hasConceptScore W2988761623C44249647 @default.
• W2988761623 hasConceptScore W2988761623C71924100 @default.
• W2988761623 hasConceptScore W2988761623C72563966 @default.
• W2988761623 hasConceptScore W2988761623C99454951 @default.
• W2988761623 hasIssue "Supplement_1" @default.
• W2988761623 hasLocation W29887616231 @default.
• W2988761623 hasOpenAccess W2988761623 @default.
• W2988761623 hasPrimaryLocation W29887616231 @default.
• W2988761623 hasRelatedWork W1516595110 @default.
• W2988761623 hasRelatedWork W1548660409 @default.
• W2988761623 hasRelatedWork W1818467446 @default.
• W2988761623 hasRelatedWork W2426018598 @default.
• W2988761623 hasRelatedWork W2490521022 @default.
• W2988761623 hasRelatedWork W2573252630 @default.
• W2988761623 hasRelatedWork W2582431155 @default.
• W2988761623 hasRelatedWork W2809220925 @default.
• W2988761623 hasRelatedWork W2943290830 @default.
• W2988761623 hasRelatedWork W4242486230 @default.
• W2988761623 hasVolume "134" @default.
• W2988761623 isParatext "false" @default.
• W2988761623 isRetracted "false" @default.
• W2988761623 magId "2988761623" @default.
• W2988761623 workType "article" @default.