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• W2988761792 abstract "Glioblastomas (GBM) are deadly brain tumors that currently do not have long-term patient treatments available. GBM overexpress the angiogenesis factor VEGF and its receptor VEGFR2. ETLD1 (epidermal growth factor, latrophilin and seven transmembrane domain-containing protein 1), a G-protein coupled receptor (GPCR) protein, we discovered as a biomarker for high-grade gliomas, is also a novel regulator of angiogenesis. Since it was established that VEGF regulates ELTD1, we wanted to establish if VEGFR2 is also associated with ELTD1, by targeted antibody inhibition. G55 glioma-bearing mice were treated with either anti-ELTD1 or anti-VEGFR2 antibodies. With the use of MRI molecular imaging probes, we were able to detect in vivo levels of either ELTD1 (anti-ELTD1 probe) or VEGFR2 (anti-VEGFR2 probe). Protein expressions were obtained for ELTD1, VEGF or VEGFR2 via immunohistochemistry (IHC). VEGFR2 levels were significantly decreased (P < 0.05) with anti-ELTD1 antibody treatment, and ELTD1 levels were significantly decreased (P < 0.05) with anti-VEGFR2 antibody treatment, both compared to untreated tumors. IHC from mouse tumor tissues established that VEGFR2 and ELTD1 were co-localized. The mouse anti-ELTD1 antibody treatment study indicated that anti-VEGFR2 antibody treatment does not significantly increase survival, decrease tumor volumes, or alter tumor perfusion (measured as relative cerebral blood flow or rCBF). Conversely, anti-ELTD1 antibody treatment was able to significantly increase animal survival (P < 0.01), decrease tumor volumes (P < 0.05), and reduce change in rCBF (P < 0.001), when compared to untreated or IgG-treated tumor bearing mice. Anti-ELTD1 antibody therapy could be beneficial in targeting ELTD1, as well as simultaneously affecting VEGFR2, as a possible GBM treatment." @default.
• W2988761792 created "2019-11-22" @default.
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• W2988761792 date "2019-01-01" @default.
• W2988761792 modified "2023-09-23" @default.
• W2988761792 title "Targeting ELTD1, an angiogenesis marker for glioblastoma (GBM), also affects VEGFR2: molecular-targeted MRI assessment." @default.
• W2988761792 cites W1536103630 @default.
• W2988761792 cites W1575487317 @default.
• W2988761792 cites W1670599640 @default.
• W2988761792 cites W172183759 @default.
• W2988761792 cites W1755000358 @default.
• W2988761792 cites W1845986149 @default.
• W2988761792 cites W1874566015 @default.
• W2988761792 cites W1901239216 @default.
• W2988761792 cites W1964182705 @default.
• W2988761792 cites W1967292086 @default.
• W2988761792 cites W1972367449 @default.
• W2988761792 cites W1976019207 @default.
• W2988761792 cites W1976099054 @default.
• W2988761792 cites W1981612052 @default.
• W2988761792 cites W1982393334 @default.
• W2988761792 cites W1983227350 @default.
• W2988761792 cites W1984604959 @default.
• W2988761792 cites W1984740575 @default.
• W2988761792 cites W1995176466 @default.
• W2988761792 cites W1995321803 @default.
• W2988761792 cites W2000043742 @default.
• W2988761792 cites W2000553618 @default.
• W2988761792 cites W2002727873 @default.
• W2988761792 cites W2003582067 @default.
• W2988761792 cites W2011788217 @default.
• W2988761792 cites W2012678565 @default.
• W2988761792 cites W2014115208 @default.
• W2988761792 cites W2015323647 @default.
• W2988761792 cites W2016038944 @default.
• W2988761792 cites W2016640764 @default.
• W2988761792 cites W2016996307 @default.
• W2988761792 cites W2018079574 @default.
• W2988761792 cites W2019226108 @default.
• W2988761792 cites W2029482740 @default.
• W2988761792 cites W2031806733 @default.
• W2988761792 cites W2040892290 @default.
• W2988761792 cites W2041563661 @default.
• W2988761792 cites W2052110007 @default.
• W2988761792 cites W2054050668 @default.
• W2988761792 cites W2058147376 @default.
• W2988761792 cites W2059407064 @default.
• W2988761792 cites W2069514245 @default.
• W2988761792 cites W2070488197 @default.
• W2988761792 cites W2074569757 @default.
• W2988761792 cites W2077390445 @default.
• W2988761792 cites W2096173332 @default.
• W2988761792 cites W2096800614 @default.
• W2988761792 cites W2097177355 @default.
• W2988761792 cites W2108295655 @default.
• W2988761792 cites W2113282518 @default.
• W2988761792 cites W2118269370 @default.
• W2988761792 cites W2118278618 @default.
• W2988761792 cites W2120521583 @default.
• W2988761792 cites W2121428690 @default.
• W2988761792 cites W2129531694 @default.
• W2988761792 cites W2130139391 @default.
• W2988761792 cites W2130748131 @default.
• W2988761792 cites W2140060467 @default.
• W2988761792 cites W2142472326 @default.
• W2988761792 cites W2148977460 @default.
• W2988761792 cites W2150429594 @default.
• W2988761792 cites W2150535801 @default.
• W2988761792 cites W2151335185 @default.
• W2988761792 cites W2152215024 @default.
• W2988761792 cites W2156807434 @default.
• W2988761792 cites W2157483153 @default.
• W2988761792 cites W2166637572 @default.
• W2988761792 cites W2166798417 @default.
• W2988761792 cites W2167923186 @default.
• W2988761792 cites W2168035548 @default.
• W2988761792 cites W2169661843 @default.
• W2988761792 cites W2170000965 @default.
• W2988761792 cites W2209572449 @default.
• W2988761792 cites W2304044561 @default.
• W2988761792 cites W2319565136 @default.
• W2988761792 cites W2337239674 @default.
• W2988761792 cites W2366536035 @default.
• W2988761792 cites W2421162531 @default.
• W2988761792 cites W2464787242 @default.
• W2988761792 cites W2471665008 @default.
• W2988761792 cites W2514059345 @default.
• W2988761792 cites W2566753678 @default.

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