FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2988798093> ?p ?o ?g. }

• W2988798093 endingPage "111861" @default.
• W2988798093 startingPage "111861" @default.
• W2988798093 abstract "DNA methylation catalyzed by M.SssI methyltransferases (MTase) has important roles in gene expression and other cellular activities, and relates to some diseases, especially cancers. Therefore, it is important to develop a sensitive sensing platform for M.SssI MTase activity assay. Here, taking zeolitic imidazolate framework-8 (ZIF-8) polyhedra as the carriers of graphene quantum dots (GQDs), GQDs-embedded ZIF-8 polyhedra (denoted as GQDs@ZIF-8 polyhedra) were successfully prepared and used as the multi-functional signal quencher to construct a novel signal-off photoelectrochemical (PEC) biosensor for M.SssI MTase activity assay. Firstly, the indium tin oxide (ITO) slice was modified with TiO2, poly(diallyldimethylammonium chloride) and CdTe quantum dots (QDs). The obtained electrode was used as the photoelectrode and labeled as ITO/TiO2/CdTe QDs. Then, single-stranded DNA (S1) was anchored on the photoelectrode surface via S-Cd bond. After hybridization between S1 and biotinylated single-stranded DNA (S2), the streptavidin (SA)-labeled GQDs@ZIF-8 polyhedra were introduced to the modified electrode via the specific reaction between biotin and SA. As the signal quencher, GQDs@ZIF-8 polyhedra could not only inhibit the photocurrent signal of the ITO/TiO2/CdTe QDs electrode due to the steric hindrance effect, but also act as peroxidase mimetics to catalyze precipitation reaction of 4-chloro-1-naphthol, resulting in the evident depression of the photocurrent signal. For the specially designed S1/S2 double-strand DNA, the decreased photocurrent was quantitatively correlated with the M.SssI MTase activity (linear response range, 0.005-150 U mL-1; detection limit, 0.004 U mL-1). The developed GQDs@ZIF-8 polyhedra and related PEC biosensor may have potential applications in clinical research and disease diagnosis." @default.
• W2988798093 created "2019-11-22" @default.
• W2988798093 creator A5012871995 @default.
• W2988798093 creator A5041737510 @default.
• W2988798093 creator A5052900941 @default.
• W2988798093 creator A5079969251 @default.
• W2988798093 creator A5081998375 @default.
• W2988798093 date "2020-02-01" @default.
• W2988798093 modified "2023-10-14" @default.
• W2988798093 title "A novel signal-off photoelectrochemical biosensor for M.SssI MTase activity assay based on GQDs@ZIF-8 polyhedra as signal quencher" @default.
• W2988798093 cites W1573323739 @default.
• W2988798093 cites W1821797507 @default.
• W2988798093 cites W1908546530 @default.
• W2988798093 cites W1969797731 @default.
• W2988798093 cites W1977995932 @default.
• W2988798093 cites W1981402604 @default.
• W2988798093 cites W1981555812 @default.
• W2988798093 cites W1988625937 @default.
• W2988798093 cites W2002297285 @default.
• W2988798093 cites W2017611256 @default.
• W2988798093 cites W2026343134 @default.
• W2988798093 cites W2035751682 @default.
• W2988798093 cites W2045569140 @default.
• W2988798093 cites W2049662309 @default.
• W2988798093 cites W2054582796 @default.
• W2988798093 cites W2076735077 @default.
• W2988798093 cites W2082747664 @default.
• W2988798093 cites W2085675301 @default.
• W2988798093 cites W2096361826 @default.
• W2988798093 cites W2106523925 @default.
• W2988798093 cites W2112004108 @default.
• W2988798093 cites W2120094396 @default.
• W2988798093 cites W2166466845 @default.
• W2988798093 cites W2167744038 @default.
• W2988798093 cites W2208284809 @default.
• W2988798093 cites W2275934507 @default.
• W2988798093 cites W2290971389 @default.
• W2988798093 cites W2300259727 @default.
• W2988798093 cites W2327158420 @default.
• W2988798093 cites W2328278396 @default.
• W2988798093 cites W2328534726 @default.
• W2988798093 cites W2330485671 @default.
• W2988798093 cites W2330967235 @default.
• W2988798093 cites W2411160557 @default.
• W2988798093 cites W2522238430 @default.
• W2988798093 cites W2751391402 @default.
• W2988798093 cites W2770639799 @default.
• W2988798093 cites W2793646181 @default.
• W2988798093 cites W2800359023 @default.
• W2988798093 cites W2801179335 @default.
• W2988798093 cites W2801505930 @default.
• W2988798093 cites W2894819414 @default.
• W2988798093 cites W2914216999 @default.
• W2988798093 cites W2922514634 @default.
• W2988798093 cites W2931314503 @default.
• W2988798093 cites W2948956012 @default.
• W2988798093 doi "https://doi.org/10.1016/j.bios.2019.111861" @default.
• W2988798093 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31740258" @default.
• W2988798093 hasPublicationYear "2020" @default.
• W2988798093 type Work @default.
• W2988798093 sameAs 2988798093 @default.
• W2988798093 citedByCount "52" @default.
• W2988798093 countsByYear W29887980932020 @default.
• W2988798093 countsByYear W29887980932021 @default.
• W2988798093 countsByYear W29887980932022 @default.
• W2988798093 countsByYear W29887980932023 @default.
• W2988798093 crossrefType "journal-article" @default.
• W2988798093 hasAuthorship W2988798093A5012871995 @default.
• W2988798093 hasAuthorship W2988798093A5041737510 @default.
• W2988798093 hasAuthorship W2988798093A5052900941 @default.
• W2988798093 hasAuthorship W2988798093A5079969251 @default.
• W2988798093 hasAuthorship W2988798093A5081998375 @default.
• W2988798093 hasConcept C124657808 @default.
• W2988798093 hasConcept C147789679 @default.
• W2988798093 hasConcept C160756335 @default.
• W2988798093 hasConcept C171250308 @default.
• W2988798093 hasConcept C17525397 @default.
• W2988798093 hasConcept C185592680 @default.
• W2988798093 hasConcept C192562407 @default.
• W2988798093 hasConcept C2777869211 @default.
• W2988798093 hasConcept C2777959998 @default.
• W2988798093 hasConcept C2779845233 @default.
• W2988798093 hasConcept C30080830 @default.
• W2988798093 hasConcept C49040817 @default.
• W2988798093 hasConcept C52859227 @default.
• W2988798093 hasConcept C55493867 @default.
• W2988798093 hasConceptScore W2988798093C124657808 @default.
• W2988798093 hasConceptScore W2988798093C147789679 @default.
• W2988798093 hasConceptScore W2988798093C160756335 @default.
• W2988798093 hasConceptScore W2988798093C171250308 @default.
• W2988798093 hasConceptScore W2988798093C17525397 @default.
• W2988798093 hasConceptScore W2988798093C185592680 @default.
• W2988798093 hasConceptScore W2988798093C192562407 @default.
• W2988798093 hasConceptScore W2988798093C2777869211 @default.
• W2988798093 hasConceptScore W2988798093C2777959998 @default.
• W2988798093 hasConceptScore W2988798093C2779845233 @default.
• W2988798093 hasConceptScore W2988798093C30080830 @default.
• W2988798093 hasConceptScore W2988798093C49040817 @default.

• next