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• W2988799432 abstract "Individuals with concurrent tuberculosis (TB) and Type 2 diabetes (DM) have a higher risk of adverse outcomes. To better understand potential immunological differences, we utilized a comprehensive panel to characterize pro-inflammatory and pro-resolving (i.e., mediators involved in the resolution of inflammation) lipid mediators in individuals with TB and TB-DM. A nested cross-sectional study of 40 individuals (20 newly diagnosed DM and 20 without DM) was conducted within a cohort of individuals with active drug-susceptible treatment-naïve pulmonary TB. Lipid mediators were quantified in serum samples through lipid mediator profiling. We conducted correlation-based analysis of these mediators. Overall, the arachidonic acid-derived leukotriene and prostaglandin families were the most abundant pro-inflammatory lipid mediators, while lipoxins and maresins families were the most abundant pro-resolving lipid mediators in individuals with TB and TB-DM. Individuals with TB-DM had increased correlations and connectivity with both pro-inflammatory and pro-resolving lipid mediators compared to those with TB alone. We identified the most abundant lipid mediator metabolomes in circulation among individuals with TB and TB-DM; in addition, our data shows a substantial number of significant correlations between both pro-inflammatory and pro-resolving lipid mediators in individuals with TB-DM, delineating a molecular balance that potentially defines this comorbidity." @default.
• W2988799432 created "2019-11-22" @default.
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• W2988799432 date "2020-04-01" @default.
• W2988799432 modified "2023-09-26" @default.
• W2988799432 title "Lipid mediators of inflammation and Resolution in individuals with tuberculosis and tuberculosis-Diabetes" @default.
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• W2988799432 doi "https://doi.org/10.1016/j.prostaglandins.2019.106398" @default.
• W2988799432 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7067657" @default.
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• W2988799432 hasPublicationYear "2020" @default.
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