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- W2988833730 abstract "Diosgenin, a natural product with steroidal structure, has a wide range of clinical applications in China. It also shows great potential in the treatment of blood clots and nerve damage. To enhance the bioavailability as well as efficacy of diosgenin, eighteen diosgenin-amino acid derivatives were designed and synthesized. The neuroprotective effects of these compounds were evaluated by SH-SY5Y cell line and the biosafety was evaluated by H9c2 cell line. The results displayed that part of the derivatives’ activities (EC50 < 20 μM) were higher than positive control edaravone (EC50 = 21.60 ± 3.04 μM), among which, DG-15 (EC50 = 6.86 ± 0.69 μM) exhibited the best neuroprotection. Meanwhile, biosafety evaluation showed that DG-15 had no cytotoxicity on H9c2 cell lines. Interestingly, combined neuroprotective and cytotoxic results, part of the derivatives without their protecting group were superior to compounds with protecting group. Subsequently, Giemsa staining and DAPI (4′,6-diamidino-2-phenylindole) staining indicated that DG-15 had a protective effect on damaged SH-SY5Y cells by reducing apoptosis. Moreover, DG-15 showed a higher role in promoting angiogenesis at high concentrations (4 mg/mL) on the chorioallantoic membrane model. This finding displayed that DG-15 had dual functions of neuroprotection and angiogenesis, which provided further insight into designing agent for the application in treatment of ischemic stroke." @default.
- W2988833730 created "2019-11-22" @default.
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- W2988833730 date "2019-11-07" @default.
- W2988833730 modified "2023-09-26" @default.
- W2988833730 title "Design, Synthesis and Biological Evaluation of Diosgenin-Amino Acid Derivatives with Dual Functions of Neuroprotection and Angiogenesis" @default.
- W2988833730 cites W1911185606 @default.
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- W2988833730 cites W1999338774 @default.
- W2988833730 cites W2001596696 @default.
- W2988833730 cites W2003641375 @default.
- W2988833730 cites W2009000980 @default.
- W2988833730 cites W2010482555 @default.
- W2988833730 cites W2011458226 @default.
- W2988833730 cites W2015023087 @default.
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- W2988833730 doi "https://doi.org/10.3390/molecules24224025" @default.
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