Matches in SemOpenAlex for { <https://semopenalex.org/work/W2988927056> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2988927056 abstract "Abstract Glioblastoma (GBM) is one of the most lethal human tumors with a highly infiltrative phenotype. Although invasiveness is related to poor prognosis, no therapeutic intervention targeting invasion is available for treatment of GBM patient, partially due to the diversity and redundancy of invasion machinery genes. In this regard, additional identification of deterministic and causative targets for invasion is required. Invasiveness of GBM patients and matched tumorspheres (TSs) was quantified using MR images and collagen-based 3D invasion assays, respectively. Transcriptome of GBM samples were obtained using microarrays. The knockdown effects of invasion-deterministic transcription factors (TFs) were evaluated using western blot and mouse orthotopic xenograft model. This study is aimed to identify novel transcriptional regulatory networks, which can collectively modulate invasion-involved genes in GBM. After classification of 23 GBM patient-derived TSs into low and high invasion groups, we applied single sample gene set enrichment analysis using TF target gene sets. According to enrichment scores, TFs responsible for low (PCBP1) and high (STAT3 and SRF) invasiveness were identified. Consistently with computational prediction, knockdown of PCBP1 significantly increased invasion area, whereas knockdown of STAT3 or SRF significantly suppressed invasive properties in all tested TSs. Notably, MR images showed coherent patterns with invasion of originated TS, and high invasiveness was associated with poor prognosis. In addition, mouse orthotopic xenograft model using TSs with down-regulated STAT3 or SRF showed significantly prolonged survival time compared to control. We identified invasion-deterministic TFs in glioblastoma using integrative transcriptome analysis. Owing to relationship among these transcriptional regulatory networks, invasive phenotype, and prognosis, we suggest that these TFs as novel drug targets for GBM." @default.
- W2988927056 created "2019-11-22" @default.
- W2988927056 creator A5008217338 @default.
- W2988927056 creator A5022027749 @default.
- W2988927056 creator A5027655972 @default.
- W2988927056 creator A5031241864 @default.
- W2988927056 creator A5036216946 @default.
- W2988927056 creator A5039149335 @default.
- W2988927056 creator A5049496700 @default.
- W2988927056 creator A5071684275 @default.
- W2988927056 creator A5084704011 @default.
- W2988927056 date "2019-11-01" @default.
- W2988927056 modified "2023-09-26" @default.
- W2988927056 title "ANGI-01. IDENTIFICATION OF INVASION-DETERMINISTIC TRANSCRIPTION FACTORS IN GLIOBLASTOMA USING INTEGRATIVE TRANSCRIPTOME ANALYSIS" @default.
- W2988927056 doi "https://doi.org/10.1093/neuonc/noz175.112" @default.
- W2988927056 hasPublicationYear "2019" @default.
- W2988927056 type Work @default.
- W2988927056 sameAs 2988927056 @default.
- W2988927056 citedByCount "0" @default.
- W2988927056 crossrefType "journal-article" @default.
- W2988927056 hasAuthorship W2988927056A5008217338 @default.
- W2988927056 hasAuthorship W2988927056A5022027749 @default.
- W2988927056 hasAuthorship W2988927056A5027655972 @default.
- W2988927056 hasAuthorship W2988927056A5031241864 @default.
- W2988927056 hasAuthorship W2988927056A5036216946 @default.
- W2988927056 hasAuthorship W2988927056A5039149335 @default.
- W2988927056 hasAuthorship W2988927056A5049496700 @default.
- W2988927056 hasAuthorship W2988927056A5071684275 @default.
- W2988927056 hasAuthorship W2988927056A5084704011 @default.
- W2988927056 hasBestOaLocation W29889270561 @default.
- W2988927056 hasConcept C104317684 @default.
- W2988927056 hasConcept C116834253 @default.
- W2988927056 hasConcept C138885662 @default.
- W2988927056 hasConcept C150194340 @default.
- W2988927056 hasConcept C162317418 @default.
- W2988927056 hasConcept C179926584 @default.
- W2988927056 hasConcept C18903297 @default.
- W2988927056 hasConcept C2776194525 @default.
- W2988927056 hasConcept C41895202 @default.
- W2988927056 hasConcept C502942594 @default.
- W2988927056 hasConcept C54355233 @default.
- W2988927056 hasConcept C70721500 @default.
- W2988927056 hasConcept C86339819 @default.
- W2988927056 hasConcept C86803240 @default.
- W2988927056 hasConceptScore W2988927056C104317684 @default.
- W2988927056 hasConceptScore W2988927056C116834253 @default.
- W2988927056 hasConceptScore W2988927056C138885662 @default.
- W2988927056 hasConceptScore W2988927056C150194340 @default.
- W2988927056 hasConceptScore W2988927056C162317418 @default.
- W2988927056 hasConceptScore W2988927056C179926584 @default.
- W2988927056 hasConceptScore W2988927056C18903297 @default.
- W2988927056 hasConceptScore W2988927056C2776194525 @default.
- W2988927056 hasConceptScore W2988927056C41895202 @default.
- W2988927056 hasConceptScore W2988927056C502942594 @default.
- W2988927056 hasConceptScore W2988927056C54355233 @default.
- W2988927056 hasConceptScore W2988927056C70721500 @default.
- W2988927056 hasConceptScore W2988927056C86339819 @default.
- W2988927056 hasConceptScore W2988927056C86803240 @default.
- W2988927056 hasLocation W29889270561 @default.
- W2988927056 hasLocation W29889270562 @default.
- W2988927056 hasOpenAccess W2988927056 @default.
- W2988927056 hasPrimaryLocation W29889270561 @default.
- W2988927056 hasRelatedWork W1982362925 @default.
- W2988927056 hasRelatedWork W2005060346 @default.
- W2988927056 hasRelatedWork W2053985040 @default.
- W2988927056 hasRelatedWork W2062078967 @default.
- W2988927056 hasRelatedWork W2071595801 @default.
- W2988927056 hasRelatedWork W2071870489 @default.
- W2988927056 hasRelatedWork W2083687933 @default.
- W2988927056 hasRelatedWork W2114226866 @default.
- W2988927056 hasRelatedWork W2225209056 @default.
- W2988927056 hasRelatedWork W2249565108 @default.
- W2988927056 hasRelatedWork W2336533109 @default.
- W2988927056 hasRelatedWork W2338770766 @default.
- W2988927056 hasRelatedWork W2427655740 @default.
- W2988927056 hasRelatedWork W2491372087 @default.
- W2988927056 hasRelatedWork W2609049339 @default.
- W2988927056 hasRelatedWork W2613151636 @default.
- W2988927056 hasRelatedWork W2742434807 @default.
- W2988927056 hasRelatedWork W2955742145 @default.
- W2988927056 hasRelatedWork W2962339389 @default.
- W2988927056 hasRelatedWork W2988051862 @default.
- W2988927056 isParatext "false" @default.
- W2988927056 isRetracted "false" @default.
- W2988927056 magId "2988927056" @default.
- W2988927056 workType "article" @default.