FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2988945504> ?p ?o ?g. }

• W2988945504 endingPage "819" @default.
• W2988945504 startingPage "808" @default.
• W2988945504 abstract "BACKGROUND AND AIMS Nonalcoholic fatty liver disease (NAFLD) is now the most common liver condition. Predicting its progression could help clinicians manage and potentially prevent complications. We evaluated the independent and joint effects of metabolic traits on the risk of cirrhosis and hepatocellular carcinoma (HCC) among patients with NAFLD. APPROACH AND RESULTS We assembled a retrospective cohort of patients with NAFLD diagnosed at 130 facilities in the Veterans Administration between January 1, 2004, and December 31, 2008, with follow-up through December 31, 2015. We performed competing risk-adjusted cause-specific Cox models to evaluate the effects of metabolic traits (diabetes, hypertension, dyslipidemia, obesity) as additive or combined indicators on time to develop cirrhosis or HCC or a composite endpoint of both. Of the 271,906 patients, 22,794 developed cirrhosis, and 253 developed HCC during a mean of 9 years follow-up. At baseline, the mean body mass index was 31.6 (SD, 5.6), 28.7% had diabetes, 70.3% had hypertension, and 62.3% had dyslipidemia with substantial overlap among these traits. The risk of progression was the lowest in patients with only one or no metabolic trait. There was a stepwise increase in risk with each additional metabolic trait. Compared with patients with no metabolic trait, patients with both hypertension and dyslipidemia had 1.8-fold higher risk of progression to cirrhosis/HCC (hazard ratio [HR] = 1.8, 95% confidence interval [CI] = 1.59-2.06); the risk was 2.6-fold higher in patients with diabetes, obesity, dyslipidemia, and hypertension (HR = 2.6, 95% CI = 2.3-2.9). These associations were stronger for HCC. Diabetes had the strongest association with HCC in this cohort. CONCLUSIONS Each additional metabolic trait increased the risk of cirrhosis and HCC in patients with NAFLD. Diabetes conferred the highest risk of progression to HCC. Patients with diabetes and coexisting hypertension and obesity may be important targets for secondary prevention." @default.
• W2988945504 created "2019-11-22" @default.
• W2988945504 creator A5019712754 @default.
• W2988945504 creator A5027343826 @default.
• W2988945504 creator A5037638631 @default.
• W2988945504 creator A5058164127 @default.
• W2988945504 creator A5060297613 @default.
• W2988945504 creator A5064421397 @default.
• W2988945504 creator A5075525513 @default.
• W2988945504 creator A5086965411 @default.
• W2988945504 date "2020-02-26" @default.
• W2988945504 modified "2023-10-18" @default.
• W2988945504 title "Effect of Metabolic Traits on the Risk of Cirrhosis and Hepatocellular Cancer in Nonalcoholic Fatty Liver Disease" @default.
• W2988945504 cites W1547708675 @default.
• W2988945504 cites W1965423912 @default.
• W2988945504 cites W1975567145 @default.
• W2988945504 cites W1976236072 @default.
• W2988945504 cites W1987934823 @default.
• W2988945504 cites W1996559225 @default.
• W2988945504 cites W1997425045 @default.
• W2988945504 cites W2002034811 @default.
• W2988945504 cites W2038429516 @default.
• W2988945504 cites W2047556186 @default.
• W2988945504 cites W2053435298 @default.
• W2988945504 cites W2056934001 @default.
• W2988945504 cites W2059251195 @default.
• W2988945504 cites W2059630954 @default.
• W2988945504 cites W2066019849 @default.
• W2988945504 cites W2077684198 @default.
• W2988945504 cites W2081324449 @default.
• W2988945504 cites W2089535377 @default.
• W2988945504 cites W2129639561 @default.
• W2988945504 cites W2145619783 @default.
• W2988945504 cites W2165778365 @default.
• W2988945504 cites W2204688218 @default.
• W2988945504 cites W2759997926 @default.
• W2988945504 cites W2888259312 @default.
• W2988945504 doi "https://doi.org/10.1002/hep.31014" @default.
• W2988945504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31675427" @default.
• W2988945504 hasPublicationYear "2020" @default.
• W2988945504 type Work @default.
• W2988945504 sameAs 2988945504 @default.
• W2988945504 citedByCount "152" @default.
• W2988945504 countsByYear W29889455042020 @default.
• W2988945504 countsByYear W29889455042021 @default.
• W2988945504 countsByYear W29889455042022 @default.
• W2988945504 countsByYear W29889455042023 @default.
• W2988945504 crossrefType "journal-article" @default.
• W2988945504 hasAuthorship W2988945504A5019712754 @default.
• W2988945504 hasAuthorship W2988945504A5027343826 @default.
• W2988945504 hasAuthorship W2988945504A5037638631 @default.
• W2988945504 hasAuthorship W2988945504A5058164127 @default.
• W2988945504 hasAuthorship W2988945504A5060297613 @default.
• W2988945504 hasAuthorship W2988945504A5064421397 @default.
• W2988945504 hasAuthorship W2988945504A5075525513 @default.
• W2988945504 hasAuthorship W2988945504A5086965411 @default.
• W2988945504 hasConcept C126322002 @default.
• W2988945504 hasConcept C134018914 @default.
• W2988945504 hasConcept C207103383 @default.
• W2988945504 hasConcept C2776954865 @default.
• W2988945504 hasConcept C2777214474 @default.
• W2988945504 hasConcept C2778019345 @default.
• W2988945504 hasConcept C2778096610 @default.
• W2988945504 hasConcept C2778772119 @default.
• W2988945504 hasConcept C2779134260 @default.
• W2988945504 hasConcept C2780221984 @default.
• W2988945504 hasConcept C2780578515 @default.
• W2988945504 hasConcept C44249647 @default.
• W2988945504 hasConcept C511355011 @default.
• W2988945504 hasConcept C555293320 @default.
• W2988945504 hasConcept C71924100 @default.
• W2988945504 hasConcept C90924648 @default.
• W2988945504 hasConceptScore W2988945504C126322002 @default.
• W2988945504 hasConceptScore W2988945504C134018914 @default.
• W2988945504 hasConceptScore W2988945504C207103383 @default.
• W2988945504 hasConceptScore W2988945504C2776954865 @default.
• W2988945504 hasConceptScore W2988945504C2777214474 @default.
• W2988945504 hasConceptScore W2988945504C2778019345 @default.
• W2988945504 hasConceptScore W2988945504C2778096610 @default.
• W2988945504 hasConceptScore W2988945504C2778772119 @default.
• W2988945504 hasConceptScore W2988945504C2779134260 @default.
• W2988945504 hasConceptScore W2988945504C2780221984 @default.
• W2988945504 hasConceptScore W2988945504C2780578515 @default.
• W2988945504 hasConceptScore W2988945504C44249647 @default.
• W2988945504 hasConceptScore W2988945504C511355011 @default.
• W2988945504 hasConceptScore W2988945504C555293320 @default.
• W2988945504 hasConceptScore W2988945504C71924100 @default.
• W2988945504 hasConceptScore W2988945504C90924648 @default.
• W2988945504 hasIssue "3" @default.
• W2988945504 hasLocation W29889455041 @default.
• W2988945504 hasLocation W29889455042 @default.
• W2988945504 hasOpenAccess W2988945504 @default.
• W2988945504 hasPrimaryLocation W29889455041 @default.
• W2988945504 hasRelatedWork W1966097884 @default.
• W2988945504 hasRelatedWork W1973256449 @default.
• W2988945504 hasRelatedWork W2002530672 @default.
• W2988945504 hasRelatedWork W2099963971 @default.
• W2988945504 hasRelatedWork W2185589346 @default.

• next