Matches in SemOpenAlex for { <https://semopenalex.org/work/W2988956944> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2988956944 endingPage "1345" @default.
- W2988956944 startingPage "1339" @default.
- W2988956944 abstract "Background: The Lémann Index (LI) was recently developed to evaluate the cumulative bowel damage in patients with Crohn’s disease (CD).Aims: To search for a difference between adalimumab and azathioprine to halt the progression of bowel damage in active CD, using the LI.Methods: A single-centre, retrospective study was conducted. Patients with CD were included if they had colonoscopy and magnetic resonance enterography performed within 4 months from the start of adalimumab or azathioprine and repeated after 12 months of therapy. Primary outcome was reached if the increase of LI after 12 months of treatment was <0.3, the drug was not stopped, and the use of systemic steroids was continued for no more than 3 months.Results: Ninety-one patients were enrolled, 31 (34.1%) of them treated with adalimumab and 60 (65.9%) with azathioprine. Sixty-seven percent of patients treated with adalimumab reached the primary outcome compared to 28.3% of patients treated with azathioprine (p = .0006). The LI in the group on adalimumab therapy decreased after 12 months (from 9.9 to 8.8), while in the group on azathioprine therapy it increased (from 7.7 to 8.8).Conclusion: Treatment with adalimumab halts the progression of bowel damage in CD while that with azathioprine does not." @default.
- W2988956944 created "2019-11-22" @default.
- W2988956944 creator A5002692560 @default.
- W2988956944 creator A5033132010 @default.
- W2988956944 creator A5036406339 @default.
- W2988956944 creator A5039214771 @default.
- W2988956944 creator A5058663033 @default.
- W2988956944 creator A5067828196 @default.
- W2988956944 creator A5079090669 @default.
- W2988956944 creator A5089401525 @default.
- W2988956944 date "2019-11-02" @default.
- W2988956944 modified "2023-09-26" @default.
- W2988956944 title "Adalimumab versus azathioprine to halt the progression of bowel damage in Crohn’s disease: application of Lémann Index" @default.
- W2988956944 cites W1979692160 @default.
- W2988956944 cites W2138687960 @default.
- W2988956944 cites W2523706394 @default.
- W2988956944 cites W2547337719 @default.
- W2988956944 cites W2588951567 @default.
- W2988956944 cites W2729081337 @default.
- W2988956944 cites W2738275860 @default.
- W2988956944 cites W2765701261 @default.
- W2988956944 cites W2892098637 @default.
- W2988956944 cites W2908459564 @default.
- W2988956944 cites W2915543214 @default.
- W2988956944 doi "https://doi.org/10.1080/00365521.2019.1686057" @default.
- W2988956944 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31692395" @default.
- W2988956944 hasPublicationYear "2019" @default.
- W2988956944 type Work @default.
- W2988956944 sameAs 2988956944 @default.
- W2988956944 citedByCount "6" @default.
- W2988956944 countsByYear W29889569442020 @default.
- W2988956944 countsByYear W29889569442021 @default.
- W2988956944 countsByYear W29889569442022 @default.
- W2988956944 countsByYear W29889569442023 @default.
- W2988956944 crossrefType "journal-article" @default.
- W2988956944 hasAuthorship W2988956944A5002692560 @default.
- W2988956944 hasAuthorship W2988956944A5033132010 @default.
- W2988956944 hasAuthorship W2988956944A5036406339 @default.
- W2988956944 hasAuthorship W2988956944A5039214771 @default.
- W2988956944 hasAuthorship W2988956944A5058663033 @default.
- W2988956944 hasAuthorship W2988956944A5067828196 @default.
- W2988956944 hasAuthorship W2988956944A5079090669 @default.
- W2988956944 hasAuthorship W2988956944A5089401525 @default.
- W2988956944 hasBestOaLocation W29889569442 @default.
- W2988956944 hasConcept C121608353 @default.
- W2988956944 hasConcept C126322002 @default.
- W2988956944 hasConcept C141071460 @default.
- W2988956944 hasConcept C2776485726 @default.
- W2988956944 hasConcept C2776760755 @default.
- W2988956944 hasConcept C2778260677 @default.
- W2988956944 hasConcept C2778435480 @default.
- W2988956944 hasConcept C2779134260 @default.
- W2988956944 hasConcept C2779280984 @default.
- W2988956944 hasConcept C2780132546 @default.
- W2988956944 hasConcept C526805850 @default.
- W2988956944 hasConcept C70917649 @default.
- W2988956944 hasConcept C71924100 @default.
- W2988956944 hasConcept C90924648 @default.
- W2988956944 hasConceptScore W2988956944C121608353 @default.
- W2988956944 hasConceptScore W2988956944C126322002 @default.
- W2988956944 hasConceptScore W2988956944C141071460 @default.
- W2988956944 hasConceptScore W2988956944C2776485726 @default.
- W2988956944 hasConceptScore W2988956944C2776760755 @default.
- W2988956944 hasConceptScore W2988956944C2778260677 @default.
- W2988956944 hasConceptScore W2988956944C2778435480 @default.
- W2988956944 hasConceptScore W2988956944C2779134260 @default.
- W2988956944 hasConceptScore W2988956944C2779280984 @default.
- W2988956944 hasConceptScore W2988956944C2780132546 @default.
- W2988956944 hasConceptScore W2988956944C526805850 @default.
- W2988956944 hasConceptScore W2988956944C70917649 @default.
- W2988956944 hasConceptScore W2988956944C71924100 @default.
- W2988956944 hasConceptScore W2988956944C90924648 @default.
- W2988956944 hasIssue "11" @default.
- W2988956944 hasLocation W29889569441 @default.
- W2988956944 hasLocation W29889569442 @default.
- W2988956944 hasLocation W29889569443 @default.
- W2988956944 hasOpenAccess W2988956944 @default.
- W2988956944 hasPrimaryLocation W29889569441 @default.
- W2988956944 hasRelatedWork W1976932609 @default.
- W2988956944 hasRelatedWork W2062275660 @default.
- W2988956944 hasRelatedWork W2115797209 @default.
- W2988956944 hasRelatedWork W2116538321 @default.
- W2988956944 hasRelatedWork W2135039841 @default.
- W2988956944 hasRelatedWork W2316734434 @default.
- W2988956944 hasRelatedWork W2334467272 @default.
- W2988956944 hasRelatedWork W2781372331 @default.
- W2988956944 hasRelatedWork W2988956944 @default.
- W2988956944 hasRelatedWork W3023349297 @default.
- W2988956944 hasVolume "54" @default.
- W2988956944 isParatext "false" @default.
- W2988956944 isRetracted "false" @default.
- W2988956944 magId "2988956944" @default.
- W2988956944 workType "article" @default.