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• W2988967042 endingPage "102354" @default.
• W2988967042 startingPage "102354" @default.
• W2988967042 abstract "Abstract Mothers giving birth to children with manifestations of neonatal lupus (NL) represent a unique population at risk for the development of clinically evident pathologic autoimmunity since many are asymptomatic and only become aware of anti-SSA/Ro positivity (anti-Ro+) based on heart block in their fetus. Accordingly, we hypothesized that the microbiome in saliva is associated with the development of autoreactivity and in some cases the progression in health status from benign to overt clinical disease including Sjogren's syndrome (SS) and systemic lupus erythematosus (SLE). The study comprised a clinical spectrum of anti-Ro+ mothers, all of whom gave birth to a child with NL: 9 were asymptomatic or had an undifferentiated autoimmune disease (Asym/UAS) and 16 fulfilled criteria for SS and/or SLE. Microbial diversity was reduced across all levels from kingdom to species for the anti-Ro+ mothers vs healthy controls; however, there were no significant differences between Asym/UAS and SS/SLE mothers. Relative abundance of Proteobacteria and more specifically class Betaproteobacteria decreased with clinical severity (healthy controls" @default.
• W2988967042 created "2019-11-22" @default.
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• W2988967042 date "2020-02-01" @default.
• W2988967042 modified "2023-10-03" @default.
• W2988967042 title "Salivary dysbiosis and the clinical spectrum in anti-Ro positive mothers of children with neonatal lupus" @default.
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• W2988967042 doi "https://doi.org/10.1016/j.jaut.2019.102354" @default.
• W2988967042 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7192221" @default.
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