FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2988968263> ?p ?o ?g. }

• W2988968263 abstract "Nucleosomes restrict DNA accessibility throughout eukaryotic genomes, with repercussions for replication, transcription, and other DNA-templated processes. How this globally restrictive organization emerged during evolution remains poorly understood. Here, to better understand the challenges associated with establishing globally restrictive chromatin, we express histones in a naive system that has not evolved to deal with nucleosomal structures: Escherichia coli. We find that histone proteins from the archaeon Methanothermus fervidus assemble on the E. coli chromosome in vivo and protect DNA from micrococcal nuclease digestion, allowing us to map binding footprints genome-wide. We show that higher nucleosome occupancy at promoters is associated with lower transcript levels, consistent with local repressive effects. Surprisingly, however, this sudden enforced chromatinization has only mild repercussions for growth unless cells experience topological stress. Our results suggest that histones can become established as ubiquitous chromatin proteins without interfering critically with key DNA-templated processes." @default.
• W2988968263 created "2019-11-22" @default.
• W2988968263 creator A5002409526 @default.
• W2988968263 creator A5002827694 @default.
• W2988968263 creator A5005881819 @default.
• W2988968263 creator A5030585717 @default.
• W2988968263 creator A5073285869 @default.
• W2988968263 date "2019-11-06" @default.
• W2988968263 modified "2023-10-03" @default.
• W2988968263 title "Chromatinization of Escherichia coli with archaeal histones" @default.
• W2988968263 cites W1575224321 @default.
• W2988968263 cites W1581290644 @default.
• W2988968263 cites W1583942422 @default.
• W2988968263 cites W1968984443 @default.
• W2988968263 cites W1982313259 @default.
• W2988968263 cites W1983291559 @default.
• W2988968263 cites W1996425050 @default.
• W2988968263 cites W1997003749 @default.
• W2988968263 cites W1999059147 @default.
• W2988968263 cites W2000142302 @default.
• W2988968263 cites W2001300203 @default.
• W2988968263 cites W2006998897 @default.
• W2988968263 cites W2008203273 @default.
• W2988968263 cites W2014589605 @default.
• W2988968263 cites W2037731823 @default.
• W2988968263 cites W2037913229 @default.
• W2988968263 cites W2043099640 @default.
• W2988968263 cites W2050421684 @default.
• W2988968263 cites W2066965664 @default.
• W2988968263 cites W2067542353 @default.
• W2988968263 cites W2096533034 @default.
• W2988968263 cites W2096873549 @default.
• W2988968263 cites W2098421068 @default.
• W2988968263 cites W2102619694 @default.
• W2988968263 cites W2113843263 @default.
• W2988968263 cites W2113976808 @default.
• W2988968263 cites W2117385832 @default.
• W2988968263 cites W2121365413 @default.
• W2988968263 cites W2129718014 @default.
• W2988968263 cites W2142255157 @default.
• W2988968263 cites W2147680973 @default.
• W2988968263 cites W2151605074 @default.
• W2988968263 cites W2154653939 @default.
• W2988968263 cites W2158525510 @default.
• W2988968263 cites W2166394937 @default.
• W2988968263 cites W2170551349 @default.
• W2988968263 cites W2179438025 @default.
• W2988968263 cites W2313116527 @default.
• W2988968263 cites W2346007989 @default.
• W2988968263 cites W2404280981 @default.
• W2988968263 cites W2467964007 @default.
• W2988968263 cites W2517882226 @default.
• W2988968263 cites W2576036275 @default.
• W2988968263 cites W2743255823 @default.
• W2988968263 cites W2743709860 @default.
• W2988968263 cites W2744352902 @default.
• W2988968263 cites W2782541724 @default.
• W2988968263 cites W2884750823 @default.
• W2988968263 cites W2892024757 @default.
• W2988968263 cites W2908472491 @default.
• W2988968263 cites W2922368400 @default.
• W2988968263 cites W2928206577 @default.
• W2988968263 cites W2951091094 @default.
• W2988968263 cites W2952873420 @default.
• W2988968263 cites W2964878452 @default.
• W2988968263 cites W2987525383 @default.
• W2988968263 doi "https://doi.org/10.7554/elife.49038" @default.
• W2988968263 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6867714" @default.
• W2988968263 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31692448" @default.
• W2988968263 hasPublicationYear "2019" @default.
• W2988968263 type Work @default.
• W2988968263 sameAs 2988968263 @default.
• W2988968263 citedByCount "20" @default.
• W2988968263 countsByYear W29889682632019 @default.
• W2988968263 countsByYear W29889682632020 @default.
• W2988968263 countsByYear W29889682632021 @default.
• W2988968263 countsByYear W29889682632022 @default.
• W2988968263 countsByYear W29889682632023 @default.
• W2988968263 crossrefType "journal-article" @default.
• W2988968263 hasAuthorship W2988968263A5002409526 @default.
• W2988968263 hasAuthorship W2988968263A5002827694 @default.
• W2988968263 hasAuthorship W2988968263A5005881819 @default.
• W2988968263 hasAuthorship W2988968263A5030585717 @default.
• W2988968263 hasAuthorship W2988968263A5073285869 @default.
• W2988968263 hasBestOaLocation W29889682631 @default.
• W2988968263 hasConcept C104317684 @default.
• W2988968263 hasConcept C139024627 @default.
• W2988968263 hasConcept C141231307 @default.
• W2988968263 hasConcept C54355233 @default.
• W2988968263 hasConcept C547475151 @default.
• W2988968263 hasConcept C552990157 @default.
• W2988968263 hasConcept C56952853 @default.
• W2988968263 hasConcept C64927066 @default.
• W2988968263 hasConcept C70721500 @default.
• W2988968263 hasConcept C83640560 @default.
• W2988968263 hasConcept C84772758 @default.
• W2988968263 hasConcept C86803240 @default.
• W2988968263 hasConcept C95444343 @default.
• W2988968263 hasConceptScore W2988968263C104317684 @default.
• W2988968263 hasConceptScore W2988968263C139024627 @default.

• next