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- W2988990585 abstract "Abstract Type 1 and Type 2 diabetes are the most common forms of diabetes and are caused by complex relationships between genetic predispositions and environmental factors. Recent studies have identified genetic susceptibility loci in diabetic patients, which are involved in insulin secretion either by inducing β-cell dysfunction or by β-cell development. The incidence of diabetes has increased in recent years due to rapidly changing environmental factors which induce epigenetic changes. Type 1 diabetes is caused by the autoimmune destruction of insulin-producing β cells by T lymphocytes, B lymphocytes, and macrophages against specific β-cell antigens, typically due to MHC genetic predispositions and an unknown environmental triggering event. Obesity, lack of physical exercise and aging in conjunction with genetic predispositions, leads to the development of Type 2 diabetes characterized by insulin resistance, impaired regulation of hepatic glucose production and progressively declining β-cell function which ultimately causes β-cell death." @default.
- W2988990585 created "2019-11-22" @default.
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- W2988990585 date "2020-01-01" @default.
- W2988990585 modified "2023-09-26" @default.
- W2988990585 title "Pathophysiology of diabetes" @default.
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- W2988990585 doi "https://doi.org/10.1016/b978-0-12-814833-4.00003-4" @default.
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