FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2988995719> ?p ?o ?g. }

• W2988995719 abstract "Abstract Background Large B cell lymphoma (DLBCL) is the most common type of non-Hodgkin’s lymphoma among adults. In some cases, DLBCL may seem similar to carcinoma cells, presenting a round, oval, or polygonal shape and clear nuclei. We found that the expression of P63 accounted for a considerable proportion of DLBCL cases. Under the circumstances, P63 expression may lead to a misdiagnosis, especially with a small biopsy. We aim to investigate the expression status and prognostic significance of P63 in a cohort of Chinese DLBCL patients. Methods P63, ΔNP63(P40), P53 and Ki67 were detected by immunohistochemistry (IHC). A ROC curve was adopted to find the best cut-off value for positive P63/P53 expression and high Ki67 expression. We defined P53 as positive when ≥50% of the tumor cells showed staining. The relationship between P63 and P53/Ki67 expression was examined. Time-to-event endpoints were estimated according to the Kaplan-Meier method. Moreover, multivariate analyses were conducted to evaluate the prognostic factors in DLBCL. Results Out of all the 159 DLBCL cases, 76 (47.8%) expressed P63 in the nuclei, while 41 (25.8%) were determined to have high expression by using a ROC cut-off value “≥6”. Examination of the different P63 isoforms revealed that the ΔNP63(P40) was unclearly and weakly expressed in only 3 cases, showing a fuzzy yellow cytoplasm. P63 expression was not correlated with subtype (GCB or non-GCB) or P53 but was correlated with a high proliferative index (Ki67). Kaplan-Meier analyses revealed that P63 expression was correlated with overall survival, and P63 positive cases showed poor survival outcomes ( P <0.05) in our cohort. Conclusions ΔNP63(P40) is a useful marker in the differential diagnosis of poorly differentiated squamous cell carcinoma versus DLBCL in small needle biopsy. P63 may be involved in DLBCL tumor progression, and it is an unfavorable prognostic marker in DLBCL. A subgroup of P63 and P53 coexpression DLBCL patients with an extremely poor prognosis should be noted." @default.
• W2988995719 created "2019-11-22" @default.
• W2988995719 creator A5000249682 @default.
• W2988995719 creator A5007568865 @default.
• W2988995719 creator A5038332765 @default.
• W2988995719 creator A5046049972 @default.
• W2988995719 creator A5051788465 @default.
• W2988995719 creator A5053881225 @default.
• W2988995719 creator A5084568848 @default.
• W2988995719 date "2019-11-11" @default.
• W2988995719 modified "2023-10-01" @default.
• W2988995719 title "Expression of P63 and its correlation with prognosis in diffuse large B-cell lymphoma: a single center experience" @default.
• W2988995719 cites W1542384754 @default.
• W2988995719 cites W1549574050 @default.
• W2988995719 cites W1908911888 @default.
• W2988995719 cites W1920254011 @default.
• W2988995719 cites W2015521789 @default.
• W2988995719 cites W2032099400 @default.
• W2988995719 cites W2034654045 @default.
• W2988995719 cites W2037934612 @default.
• W2988995719 cites W2054003852 @default.
• W2988995719 cites W2059470125 @default.
• W2988995719 cites W2062205391 @default.
• W2988995719 cites W2069813709 @default.
• W2988995719 cites W2090494026 @default.
• W2988995719 cites W2096596684 @default.
• W2988995719 cites W2100901254 @default.
• W2988995719 cites W2129919885 @default.
• W2988995719 cites W2134906851 @default.
• W2988995719 cites W2148290018 @default.
• W2988995719 cites W2278479675 @default.
• W2988995719 cites W2333647903 @default.
• W2988995719 cites W2530587853 @default.
• W2988995719 cites W2607129810 @default.
• W2988995719 cites W2759612188 @default.
• W2988995719 cites W2914312690 @default.
• W2988995719 cites W4243182105 @default.
• W2988995719 doi "https://doi.org/10.1186/s13000-019-0880-7" @default.
• W2988995719 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6844053" @default.
• W2988995719 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31711519" @default.
• W2988995719 hasPublicationYear "2019" @default.
• W2988995719 type Work @default.
• W2988995719 sameAs 2988995719 @default.
• W2988995719 citedByCount "5" @default.
• W2988995719 countsByYear W29889957192020 @default.
• W2988995719 countsByYear W29889957192021 @default.
• W2988995719 countsByYear W29889957192023 @default.
• W2988995719 crossrefType "journal-article" @default.
• W2988995719 hasAuthorship W2988995719A5000249682 @default.
• W2988995719 hasAuthorship W2988995719A5007568865 @default.
• W2988995719 hasAuthorship W2988995719A5038332765 @default.
• W2988995719 hasAuthorship W2988995719A5046049972 @default.
• W2988995719 hasAuthorship W2988995719A5051788465 @default.
• W2988995719 hasAuthorship W2988995719A5053881225 @default.
• W2988995719 hasAuthorship W2988995719A5084568848 @default.
• W2988995719 hasBestOaLocation W29889957191 @default.
• W2988995719 hasConcept C10515644 @default.
• W2988995719 hasConcept C126322002 @default.
• W2988995719 hasConcept C142724271 @default.
• W2988995719 hasConcept C143998085 @default.
• W2988995719 hasConcept C204232928 @default.
• W2988995719 hasConcept C2775934546 @default.
• W2988995719 hasConcept C2778559949 @default.
• W2988995719 hasConcept C2779338263 @default.
• W2988995719 hasConcept C2780073493 @default.
• W2988995719 hasConcept C38180746 @default.
• W2988995719 hasConcept C71924100 @default.
• W2988995719 hasConcept C86803240 @default.
• W2988995719 hasConceptScore W2988995719C10515644 @default.
• W2988995719 hasConceptScore W2988995719C126322002 @default.
• W2988995719 hasConceptScore W2988995719C142724271 @default.
• W2988995719 hasConceptScore W2988995719C143998085 @default.
• W2988995719 hasConceptScore W2988995719C204232928 @default.
• W2988995719 hasConceptScore W2988995719C2775934546 @default.
• W2988995719 hasConceptScore W2988995719C2778559949 @default.
• W2988995719 hasConceptScore W2988995719C2779338263 @default.
• W2988995719 hasConceptScore W2988995719C2780073493 @default.
• W2988995719 hasConceptScore W2988995719C38180746 @default.
• W2988995719 hasConceptScore W2988995719C71924100 @default.
• W2988995719 hasConceptScore W2988995719C86803240 @default.
• W2988995719 hasIssue "1" @default.
• W2988995719 hasLocation W29889957191 @default.
• W2988995719 hasLocation W29889957192 @default.
• W2988995719 hasLocation W29889957193 @default.
• W2988995719 hasLocation W29889957194 @default.
• W2988995719 hasLocation W29889957195 @default.
• W2988995719 hasOpenAccess W2988995719 @default.
• W2988995719 hasPrimaryLocation W29889957191 @default.
• W2988995719 hasRelatedWork W2021173905 @default.
• W2988995719 hasRelatedWork W2033063563 @default.
• W2988995719 hasRelatedWork W2060050787 @default.
• W2988995719 hasRelatedWork W2136143901 @default.
• W2988995719 hasRelatedWork W2381735876 @default.
• W2988995719 hasRelatedWork W2390523857 @default.
• W2988995719 hasRelatedWork W2391494730 @default.
• W2988995719 hasRelatedWork W2896388442 @default.
• W2988995719 hasRelatedWork W2980891769 @default.
• W2988995719 hasRelatedWork W4231882228 @default.
• W2988995719 hasVolume "14" @default.
• W2988995719 isParatext "false" @default.

• next