FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2989011424> ?p ?o ?g. }

• W2989011424 endingPage "522" @default.
• W2989011424 startingPage "522" @default.
• W2989011424 abstract "Streptococcus suis 2 (SS2) is an important zoonotic pathogen that substantially harms the swine industry and poses threats to human health. Excessive inflammation is considered to be a hallmark of SS2 infection because it is responsible for most clinical signs of SS2, especially streptococcal toxic shock-like syndrome. However, the current knowledge of SS2-induced excessive inflammation remains limited. In this study, we identified HP1717 as a novel extracellular pro-inflammatory protein in SS2 that can induce robust expression of inflammatory cytokines in RAW264.7 macrophages. Notably, the pro-inflammatory ability of HP1717 was dose-dependent and heat-sensitive, and it required the recognition of Toll-like receptor 2 (TLR2) and the phosphorylation of both extracellular signal-regulated kinases 1/2 (ERK1/2) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB). Further, by constructing a deletion mutant, we demonstrated that HP1717 significantly influenced the biosynthesis of the bacterial capsule, which plays a critical role in the virulence of SS2 by interfering with the ability of host immune cells to phagocytize and kill the pathogen. Indeed, the mutant strain displayed reduced resistance to whole-blood killing compared with the wild strain. Finally, murine experiments indicated that the deletion of hp1717 in SS2 reduced the lethality, pro-inflammatory activity, and bacterial loads in mice. Collectively, our data reveal HP1717 as a novel virulence-related factor of SS2 that can induce an excessive inflammatory response and significantly affect the bacterial capsule, thus expanding our understanding of the pathogenesis of S. suis." @default.
• W2989011424 created "2019-11-22" @default.
• W2989011424 creator A5000172900 @default.
• W2989011424 creator A5003554962 @default.
• W2989011424 creator A5011339015 @default.
• W2989011424 creator A5011878227 @default.
• W2989011424 creator A5016611275 @default.
• W2989011424 creator A5039837606 @default.
• W2989011424 creator A5061834037 @default.
• W2989011424 creator A5091136034 @default.
• W2989011424 date "2019-11-03" @default.
• W2989011424 modified "2023-10-16" @default.
• W2989011424 title "HP1717 Contributes to Streptococcus suis Virulence by Inducing an Excessive Inflammatory Response and Influencing the Biosynthesis of the Capsule" @default.
• W2989011424 cites W1597548042 @default.
• W2989011424 cites W164370040 @default.
• W2989011424 cites W1885768087 @default.
• W2989011424 cites W1978851267 @default.
• W2989011424 cites W1979709904 @default.
• W2989011424 cites W2001220508 @default.
• W2989011424 cites W2014780340 @default.
• W2989011424 cites W2019887475 @default.
• W2989011424 cites W2035046661 @default.
• W2989011424 cites W2035809673 @default.
• W2989011424 cites W2052798287 @default.
• W2989011424 cites W2054127896 @default.
• W2989011424 cites W2057659396 @default.
• W2989011424 cites W2072764420 @default.
• W2989011424 cites W2079128528 @default.
• W2989011424 cites W2090406897 @default.
• W2989011424 cites W2112248316 @default.
• W2989011424 cites W2129707556 @default.
• W2989011424 cites W2132074768 @default.
• W2989011424 cites W2151329275 @default.
• W2989011424 cites W2152794219 @default.
• W2989011424 cites W2154465191 @default.
• W2989011424 cites W2155124210 @default.
• W2989011424 cites W2157316861 @default.
• W2989011424 cites W2166755915 @default.
• W2989011424 cites W2179656941 @default.
• W2989011424 cites W2296016243 @default.
• W2989011424 cites W2340020481 @default.
• W2989011424 cites W2577600820 @default.
• W2989011424 cites W2594854482 @default.
• W2989011424 cites W2740204134 @default.
• W2989011424 cites W2789382360 @default.
• W2989011424 cites W2793430525 @default.
• W2989011424 cites W2794918530 @default.
• W2989011424 cites W2807037289 @default.
• W2989011424 cites W2887526327 @default.
• W2989011424 cites W2913963383 @default.
• W2989011424 doi "https://doi.org/10.3390/microorganisms7110522" @default.
• W2989011424 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6920816" @default.
• W2989011424 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31684161" @default.
• W2989011424 hasPublicationYear "2019" @default.
• W2989011424 type Work @default.
• W2989011424 sameAs 2989011424 @default.
• W2989011424 citedByCount "1" @default.
• W2989011424 countsByYear W29890114242021 @default.
• W2989011424 crossrefType "journal-article" @default.
• W2989011424 hasAuthorship W2989011424A5000172900 @default.
• W2989011424 hasAuthorship W2989011424A5003554962 @default.
• W2989011424 hasAuthorship W2989011424A5011339015 @default.
• W2989011424 hasAuthorship W2989011424A5011878227 @default.
• W2989011424 hasAuthorship W2989011424A5016611275 @default.
• W2989011424 hasAuthorship W2989011424A5039837606 @default.
• W2989011424 hasAuthorship W2989011424A5061834037 @default.
• W2989011424 hasAuthorship W2989011424A5091136034 @default.
• W2989011424 hasBestOaLocation W29890114241 @default.
• W2989011424 hasConcept C104317684 @default.
• W2989011424 hasConcept C136449434 @default.
• W2989011424 hasConcept C143065580 @default.
• W2989011424 hasConcept C184235292 @default.
• W2989011424 hasConcept C203014093 @default.
• W2989011424 hasConcept C2775976552 @default.
• W2989011424 hasConcept C2776460866 @default.
• W2989011424 hasConcept C2776914184 @default.
• W2989011424 hasConcept C2781090273 @default.
• W2989011424 hasConcept C2781236682 @default.
• W2989011424 hasConcept C28406088 @default.
• W2989011424 hasConcept C54355233 @default.
• W2989011424 hasConcept C60987743 @default.
• W2989011424 hasConcept C62478195 @default.
• W2989011424 hasConcept C86803240 @default.
• W2989011424 hasConcept C8891405 @default.
• W2989011424 hasConcept C89423630 @default.
• W2989011424 hasConcept C95444343 @default.
• W2989011424 hasConceptScore W2989011424C104317684 @default.
• W2989011424 hasConceptScore W2989011424C136449434 @default.
• W2989011424 hasConceptScore W2989011424C143065580 @default.
• W2989011424 hasConceptScore W2989011424C184235292 @default.
• W2989011424 hasConceptScore W2989011424C203014093 @default.
• W2989011424 hasConceptScore W2989011424C2775976552 @default.
• W2989011424 hasConceptScore W2989011424C2776460866 @default.
• W2989011424 hasConceptScore W2989011424C2776914184 @default.
• W2989011424 hasConceptScore W2989011424C2781090273 @default.
• W2989011424 hasConceptScore W2989011424C2781236682 @default.
• W2989011424 hasConceptScore W2989011424C28406088 @default.
• W2989011424 hasConceptScore W2989011424C54355233 @default.

• next