FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2989015144> ?p ?o ?g. }

• W2989015144 endingPage "113325" @default.
• W2989015144 startingPage "113325" @default.
• W2989015144 abstract "In aquatic toxicology, perhaps no pharmaceutical has been investigated more intensely than 17alpha-ethinylestradiol (EE2), the active ingredient of the birth control pill. At the turn of the century, the fields of comparative endocrinology and endocrine disruption research witnessed the emergence of omics technologies, which were rapidly adapted to characterize potential hazards associated with exposures to environmental estrogens, such as EE2. Since then, significant advances have been made by the scientific community, and as a result, much has been learned about estrogen receptor signaling in fish from environmental xenoestrogens. Vitellogenin, the egg yolk precursor protein, was identified as a major estrogen-responsive gene, establishing itself as the premier biomarker for estrogenic exposures. Omics studies have identified a plethora of estrogen responsive genes, contributing to a wealth of knowledge on estrogen-mediated regulatory networks in teleosts. There have been ~40 studies that report on transcriptome responses to EE2 in a variety of fish species (e.g., zebrafish, fathead minnows, rainbow trout, pipefish, mummichog, stickleback, cod, and others). Data on the liver and testis transcriptomes dominate in the literature and have been the subject of many EE2 studies, yet there remain knowledge gaps for other tissues, such as the spleen, kidney, and pituitary. Inter-laboratory genomics studies have revealed transcriptional networks altered by EE2 treatment in the liver; networks related to amino acid activation and protein folding are increased by EE2 while those related to xenobiotic metabolism, immune system, circulation, and triglyceride storage are suppressed. EE2-responsive networks in other tissues are not as comprehensively defined which is a knowledge gap as regulated networks are expected to be tissue-specific. On the horizon, omics studies for estrogen-mediated effects in fish include: (1) Establishing conceptual frameworks for incorporating estrogen-responsive networks into environmental monitoring programs; (2) Leveraging in vitro and computational toxicology approaches to identify chemicals associated with estrogen receptor-mediated effects in fish (e.g., male vitellogenin production); (3) Discovering new tissue-specific estrogen receptor signaling pathways in fish; and (4) Developing quantitative adverse outcome pathway predictive models for estrogen signaling. As we look ahead, research into EE2 over the past several decades can serve as a template for the array of hormones and endocrine active substances yet to be fully characterized or discovered." @default.
• W2989015144 created "2019-11-22" @default.
• W2989015144 creator A5022463943 @default.
• W2989015144 creator A5037722586 @default.
• W2989015144 creator A5070857812 @default.
• W2989015144 creator A5085283857 @default.
• W2989015144 creator A5088340387 @default.
• W2989015144 date "2020-01-01" @default.
• W2989015144 modified "2023-09-24" @default.
• W2989015144 title "Twenty years of transcriptomics, 17alpha-ethinylestradiol, and fish" @default.
• W2989015144 cites W1567684067 @default.
• W2989015144 cites W172442365 @default.
• W2989015144 cites W1820293822 @default.
• W2989015144 cites W1820386566 @default.
• W2989015144 cites W1910984409 @default.
• W2989015144 cites W1967434540 @default.
• W2989015144 cites W1974926081 @default.
• W2989015144 cites W1975813641 @default.
• W2989015144 cites W1978777023 @default.
• W2989015144 cites W1980269827 @default.
• W2989015144 cites W1987961161 @default.
• W2989015144 cites W1988676996 @default.
• W2989015144 cites W1988982572 @default.
• W2989015144 cites W1993455197 @default.
• W2989015144 cites W1994122604 @default.
• W2989015144 cites W1994865784 @default.
• W2989015144 cites W1997182869 @default.
• W2989015144 cites W2000089305 @default.
• W2989015144 cites W2000632853 @default.
• W2989015144 cites W2002277686 @default.
• W2989015144 cites W2002792636 @default.
• W2989015144 cites W2006053165 @default.
• W2989015144 cites W2007776002 @default.
• W2989015144 cites W2009048327 @default.
• W2989015144 cites W2010505362 @default.
• W2989015144 cites W2016044251 @default.
• W2989015144 cites W2018304817 @default.
• W2989015144 cites W2018322424 @default.
• W2989015144 cites W2018431533 @default.
• W2989015144 cites W2020708527 @default.
• W2989015144 cites W2021592359 @default.
• W2989015144 cites W2023373075 @default.
• W2989015144 cites W2025358151 @default.
• W2989015144 cites W2026302267 @default.
• W2989015144 cites W2031493473 @default.
• W2989015144 cites W2032594710 @default.
• W2989015144 cites W2039408930 @default.
• W2989015144 cites W2039420003 @default.
• W2989015144 cites W2044686237 @default.
• W2989015144 cites W2045734969 @default.
• W2989015144 cites W2051842115 @default.
• W2989015144 cites W2053314982 @default.
• W2989015144 cites W2060541177 @default.
• W2989015144 cites W2064149572 @default.
• W2989015144 cites W2065636600 @default.
• W2989015144 cites W2065899361 @default.
• W2989015144 cites W2066460397 @default.
• W2989015144 cites W2068932039 @default.
• W2989015144 cites W2069157996 @default.
• W2989015144 cites W2086711844 @default.
• W2989015144 cites W2089152436 @default.
• W2989015144 cites W2093395710 @default.
• W2989015144 cites W2094629498 @default.
• W2989015144 cites W2096638517 @default.
• W2989015144 cites W2098963564 @default.
• W2989015144 cites W2105110794 @default.
• W2989015144 cites W2107152433 @default.
• W2989015144 cites W2107518065 @default.
• W2989015144 cites W2110423357 @default.
• W2989015144 cites W2112127422 @default.
• W2989015144 cites W2120222884 @default.
• W2989015144 cites W2122025333 @default.
• W2989015144 cites W2122251639 @default.
• W2989015144 cites W2125454196 @default.
• W2989015144 cites W2131660346 @default.
• W2989015144 cites W2142529154 @default.
• W2989015144 cites W2143449015 @default.
• W2989015144 cites W2146796477 @default.
• W2989015144 cites W2149410074 @default.
• W2989015144 cites W2149940234 @default.
• W2989015144 cites W2152806277 @default.
• W2989015144 cites W2153808315 @default.
• W2989015144 cites W2153907510 @default.
• W2989015144 cites W2154472922 @default.
• W2989015144 cites W2157351275 @default.
• W2989015144 cites W2157550331 @default.
• W2989015144 cites W2162501134 @default.
• W2989015144 cites W2163330042 @default.
• W2989015144 cites W2167544928 @default.
• W2989015144 cites W2169412126 @default.
• W2989015144 cites W2192564392 @default.
• W2989015144 cites W22744554 @default.
• W2989015144 cites W2295139731 @default.
• W2989015144 cites W2329907539 @default.
• W2989015144 cites W2340832791 @default.
• W2989015144 cites W2394108223 @default.
• W2989015144 cites W2414639676 @default.
• W2989015144 cites W2429101022 @default.

• next