Matches in SemOpenAlex for { <https://semopenalex.org/work/W2989069730> ?p ?o ?g. }
- W2989069730 abstract "Chronic psychosocial adversity induces vulnerability to mental illnesses. Animal studies demonstrate that this may be mediated by dopaminergic dysfunction. We therefore investigated whether long-term exposure to psychosocial adversity was associated with dopamine dysfunction and its relationship to psychological and physiological responses to acute stress. Using 3,4-dihydroxy-6-[18F]-fluoro-l-phenylalanine ([18F]-DOPA) positron emission tomography (PET), we compared dopamine synthesis capacity in n = 17 human participants with high cumulative exposure to psychosocial adversity with n = 17 age- and sex-matched participants with low cumulative exposure. The PET scan took place 2 hr after the induction of acute psychosocial stress using the Montréal Imaging Stress Task to induce acute psychosocial stress. We found that dopamine synthesis correlated with subjective threat and physiological response to acute psychosocial stress in the low exposure group. Long-term exposure to psychosocial adversity was associated with dampened striatal dopaminergic function (p=0.03, d = 0.80) and that psychosocial adversity blunted physiological yet potentiated subjective responses to acute psychosocial stress. Future studies should investigate the roles of these changes in vulnerability to mental illnesses." @default.
- W2989069730 created "2019-11-22" @default.
- W2989069730 creator A5001601365 @default.
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- W2989069730 creator A5047194230 @default.
- W2989069730 creator A5058082561 @default.
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- W2989069730 date "2019-11-12" @default.
- W2989069730 modified "2023-10-14" @default.
- W2989069730 title "The effects of psychosocial stress on dopaminergic function and the acute stress response" @default.
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