Matches in SemOpenAlex for { <https://semopenalex.org/work/W2989100526> ?p ?o ?g. }
- W2989100526 endingPage "101323" @default.
- W2989100526 startingPage "101323" @default.
- W2989100526 abstract "It has long been assumed that the functions of B cells reflected the roles of antibodies. However, B cells also decisively influence immunity via antibody-independent mechanisms including the presentation of antigen to T cells and the secretion of cytokines. In fact, B cell depletion therapy improves the course of autoimmune diseases such as multiple sclerosis by removing pro-inflammatory cytokine-producing B cells rather than by reducing autoantibody levels. Remarkably, B cells can also produce anti-inflammatory cytokines, and subsequently suppress immunity, providing protection from autoimmune diseases while interfering with beneficial responses against pathogens and cancers. A major mediator of this B cell regulatory function is their secretion of IL-10. There is considerable interest in identifying the mechanisms inducing the expression of IL-10 in B cells during the course of their activation. Here, we review the molecular mechanisms controlling IL-10 expression in B cells, and the evidence that IL-10-producing B cells play a protective role in human autoimmune diseases, underlying the relevance of this immunosuppressive axis for therapy." @default.
- W2989100526 created "2019-11-22" @default.
- W2989100526 creator A5000515527 @default.
- W2989100526 creator A5078221402 @default.
- W2989100526 creator A5088900222 @default.
- W2989100526 date "2019-08-01" @default.
- W2989100526 modified "2023-09-30" @default.
- W2989100526 title "IL-10-producing regulatory B cells and plasmocytes: Molecular mechanisms and disease relevance" @default.
- W2989100526 cites W1509863491 @default.
- W2989100526 cites W1521119381 @default.
- W2989100526 cites W1782798663 @default.
- W2989100526 cites W1816536644 @default.
- W2989100526 cites W1831873206 @default.
- W2989100526 cites W1918941126 @default.
- W2989100526 cites W1966054625 @default.
- W2989100526 cites W1972272040 @default.
- W2989100526 cites W1975817555 @default.
- W2989100526 cites W1978262930 @default.
- W2989100526 cites W1980313076 @default.
- W2989100526 cites W1982132149 @default.
- W2989100526 cites W1984648075 @default.
- W2989100526 cites W1988079609 @default.
- W2989100526 cites W1990158627 @default.
- W2989100526 cites W1991090418 @default.
- W2989100526 cites W1997483664 @default.
- W2989100526 cites W2001115803 @default.
- W2989100526 cites W2009749672 @default.
- W2989100526 cites W2011225907 @default.
- W2989100526 cites W2012234169 @default.
- W2989100526 cites W2018938924 @default.
- W2989100526 cites W2019655196 @default.
- W2989100526 cites W2021850392 @default.
- W2989100526 cites W2025755006 @default.
- W2989100526 cites W2029613048 @default.
- W2989100526 cites W2031500443 @default.
- W2989100526 cites W2036068614 @default.
- W2989100526 cites W2039490597 @default.
- W2989100526 cites W2041181951 @default.
- W2989100526 cites W2045054556 @default.
- W2989100526 cites W2046517086 @default.
- W2989100526 cites W2052006922 @default.
- W2989100526 cites W2052599602 @default.
- W2989100526 cites W2053189124 @default.
- W2989100526 cites W2059509768 @default.
- W2989100526 cites W2060961033 @default.
- W2989100526 cites W2070407991 @default.
- W2989100526 cites W2072718666 @default.
- W2989100526 cites W2073580835 @default.
- W2989100526 cites W2077297620 @default.
- W2989100526 cites W2081903525 @default.
- W2989100526 cites W2084355898 @default.
- W2989100526 cites W2088373095 @default.
- W2989100526 cites W2089440945 @default.
- W2989100526 cites W2089794803 @default.
- W2989100526 cites W2092292953 @default.
- W2989100526 cites W2093195201 @default.
- W2989100526 cites W2093262780 @default.
- W2989100526 cites W2094486011 @default.
- W2989100526 cites W2095592851 @default.
- W2989100526 cites W2102821093 @default.
- W2989100526 cites W2106684817 @default.
- W2989100526 cites W2115619054 @default.
- W2989100526 cites W2125944408 @default.
- W2989100526 cites W2125945390 @default.
- W2989100526 cites W2127675457 @default.
- W2989100526 cites W2142160913 @default.
- W2989100526 cites W2142623408 @default.
- W2989100526 cites W2145103837 @default.
- W2989100526 cites W2148573039 @default.
- W2989100526 cites W2151059850 @default.
- W2989100526 cites W2151492920 @default.
- W2989100526 cites W2154132418 @default.
- W2989100526 cites W2159322723 @default.
- W2989100526 cites W2170205898 @default.
- W2989100526 cites W2171811057 @default.
- W2989100526 cites W2275847773 @default.
- W2989100526 cites W2290727383 @default.
- W2989100526 cites W2467568622 @default.
- W2989100526 cites W2540742595 @default.
- W2989100526 cites W2558290791 @default.
- W2989100526 cites W2575841092 @default.
- W2989100526 cites W2593916436 @default.
- W2989100526 cites W2601286611 @default.
- W2989100526 cites W2740394036 @default.
- W2989100526 cites W2761641189 @default.
- W2989100526 cites W2775951364 @default.
- W2989100526 cites W2802129756 @default.
- W2989100526 cites W2804868427 @default.
- W2989100526 cites W2805197831 @default.
- W2989100526 cites W2810182112 @default.
- W2989100526 cites W2878282601 @default.
- W2989100526 cites W2884379601 @default.
- W2989100526 cites W2889626186 @default.
- W2989100526 cites W2890493276 @default.
- W2989100526 cites W2901224159 @default.
- W2989100526 cites W2911775521 @default.
- W2989100526 cites W2919376499 @default.
- W2989100526 cites W2920411868 @default.