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• W2989111323 abstract "Postoperative cognitive dysfunction (POCD) is a common postoperative complication observed in patients following. Here we tested the molecular mechanisms of memory loss in hippocampus of rat POCD model. We found that high-dose propofol anesthesia significantly alleviated spatial memory loss. The proteomes and transcriptomes in hippocampus showed that hippocampal cytoskeleton related pathways were abnormal in low group while not in high group. The protein assays confirmed that hippocampal actin cytoskeleton was depolymerized in low group while maintained in high group. This study confirms that high-dose propofol anesthesia could mitigate the development of POCD and provides evidences for actin cytoskeleton associated with this syndrome." @default.
• W2989111323 created "2019-11-22" @default.
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• W2989111323 date "2019-11-01" @default.
• W2989111323 modified "2023-10-14" @default.
• W2989111323 title "High-dose Propofol Anesthesia Reduces the Occurrence of Postoperative Cognitive Dysfunction via Maintaining Cytoskeleton" @default.
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• W2989111323 doi "https://doi.org/10.1016/j.neuroscience.2019.09.024" @default.
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