Matches in SemOpenAlex for { <https://semopenalex.org/work/W2989122956> ?p ?o ?g. }
- W2989122956 endingPage "45" @default.
- W2989122956 startingPage "19" @default.
- W2989122956 abstract "Heat-shock protein 90 (HSP90) is a molecular chaperone that represents the most abundant soluble protein of the cell. This chaperone shows intrinsic ATPase activity and associates to a great number of client factors such as steroid receptors, tyrosine-kinases, transcription factors, enzymes, cytoskeletal proteins, channels, histones, etc. Because of these interactions, HSP90 is implicated in diverse biological processes that require critical and coordinated regulatory mechanisms to modulate its activity. HSP90 forms heterocomplexes with other chaperones and co-chaperones such as TPR-domain immunophilins that modulate HSP90 properties and are themselves subject of regulation. In malignancy, HSP90 is essential to preserve the metastable forms of oncoproteins that are usually mutated, overamplified, and sometimes translocated from their normal subcellular compartments. Thus, HSP90 helps to buffer the proteostasis of the cell that is assaulted by the onset of the stress generated by the malignant condition. Consequently, HSP90 is an attractive pharmacologic target, and the pharmaceutical industry has generated over the last years several advances in both the basic biology and the translational drug development around HSP90. This chapter is focused on the multiple aspects by which the HSP90 activity and that related to HSP90-binding proteins, particularly immunophilins, are regulated in malignancy." @default.
- W2989122956 created "2019-11-22" @default.
- W2989122956 creator A5036948916 @default.
- W2989122956 date "2019-01-01" @default.
- W2989122956 modified "2023-10-09" @default.
- W2989122956 title "HSP90-Based Heterocomplex as Essential Regulator for Cancer Disease" @default.
- W2989122956 cites W1493680264 @default.
- W2989122956 cites W1498855439 @default.
- W2989122956 cites W1544853593 @default.
- W2989122956 cites W1554180547 @default.
- W2989122956 cites W169736967 @default.
- W2989122956 cites W1797946869 @default.
- W2989122956 cites W1955276614 @default.
- W2989122956 cites W1964826325 @default.
- W2989122956 cites W1965038486 @default.
- W2989122956 cites W1968235572 @default.
- W2989122956 cites W1968916175 @default.
- W2989122956 cites W1970392870 @default.
- W2989122956 cites W1974793156 @default.
- W2989122956 cites W1975200549 @default.
- W2989122956 cites W1975692832 @default.
- W2989122956 cites W1975707478 @default.
- W2989122956 cites W1976419927 @default.
- W2989122956 cites W1977665741 @default.
- W2989122956 cites W1980882927 @default.
- W2989122956 cites W1981597970 @default.
- W2989122956 cites W1985604548 @default.
- W2989122956 cites W1985605910 @default.
- W2989122956 cites W1985951420 @default.
- W2989122956 cites W1986160530 @default.
- W2989122956 cites W1986630370 @default.
- W2989122956 cites W1988825409 @default.
- W2989122956 cites W1988999387 @default.
- W2989122956 cites W1989350070 @default.
- W2989122956 cites W1990011854 @default.
- W2989122956 cites W1991518694 @default.
- W2989122956 cites W1992909271 @default.
- W2989122956 cites W1994808369 @default.
- W2989122956 cites W1995288330 @default.
- W2989122956 cites W1996617163 @default.
- W2989122956 cites W1996667997 @default.
- W2989122956 cites W1998275595 @default.
- W2989122956 cites W1999715990 @default.
- W2989122956 cites W2000320359 @default.
- W2989122956 cites W2001546169 @default.
- W2989122956 cites W2005836509 @default.
- W2989122956 cites W2006845042 @default.
- W2989122956 cites W2007095168 @default.
- W2989122956 cites W2016663716 @default.
- W2989122956 cites W2017249419 @default.
- W2989122956 cites W2017258410 @default.
- W2989122956 cites W2017892333 @default.
- W2989122956 cites W2020131167 @default.
- W2989122956 cites W2020964197 @default.
- W2989122956 cites W2021227263 @default.
- W2989122956 cites W2021777937 @default.
- W2989122956 cites W2023814104 @default.
- W2989122956 cites W2026192649 @default.
- W2989122956 cites W2026295605 @default.
- W2989122956 cites W2028386203 @default.
- W2989122956 cites W2034269086 @default.
- W2989122956 cites W2034519235 @default.
- W2989122956 cites W2034943176 @default.
- W2989122956 cites W2036692010 @default.
- W2989122956 cites W2037652621 @default.
- W2989122956 cites W2039458533 @default.
- W2989122956 cites W2039792930 @default.
- W2989122956 cites W2039908108 @default.
- W2989122956 cites W2042316019 @default.
- W2989122956 cites W2042809289 @default.
- W2989122956 cites W2044038155 @default.
- W2989122956 cites W2046629597 @default.
- W2989122956 cites W2046702878 @default.
- W2989122956 cites W2049008330 @default.
- W2989122956 cites W2049219332 @default.
- W2989122956 cites W2053503219 @default.
- W2989122956 cites W2058560641 @default.
- W2989122956 cites W2058923196 @default.
- W2989122956 cites W2059122555 @default.
- W2989122956 cites W2060095764 @default.
- W2989122956 cites W2060902443 @default.
- W2989122956 cites W2063956958 @default.
- W2989122956 cites W2065639491 @default.
- W2989122956 cites W2066264348 @default.
- W2989122956 cites W2066404280 @default.
- W2989122956 cites W2067365193 @default.
- W2989122956 cites W2069563696 @default.
- W2989122956 cites W2072109709 @default.
- W2989122956 cites W2072777880 @default.
- W2989122956 cites W2074131174 @default.
- W2989122956 cites W2075879058 @default.
- W2989122956 cites W2077283763 @default.
- W2989122956 cites W2077878547 @default.
- W2989122956 cites W2078021348 @default.
- W2989122956 cites W2078805336 @default.
- W2989122956 cites W2079855764 @default.
- W2989122956 cites W2080053266 @default.
- W2989122956 cites W2080807720 @default.