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- W2989194872 abstract "The metabolism of most organisms is controlled by a diverse cast of regulatory processes, including transcriptional regulation and post-translational modifications (PTMs). Yet how metabolic control is distributed between these regulatory processes is unknown. Here we present Comparative Analysis of Regulators of Metabolism (CAROM), an approach that compares regulators based on network connectivity, flux, and essentiality of their reaction targets. Using CAROM, we analyze transcriptome, proteome, acetylome and phospho-proteome dynamics during transition to stationary phase in E. coli and S. cerevisiae . CAROM uncovered that the targets of each regulatory process shared unique metabolic properties: growth-limiting reactions were regulated by acetylation, while isozymes and futile-cycles were preferentially regulated by phosphorylation. Reversibility, essentiality, and molecular-weight further distinguished reactions controlled through diverse mechanisms. While every enzyme can be potentially regulated by multiple mechanisms, analysis of context-specific datasets reveals a conserved partitioning of metabolic regulation based on reaction attributes." @default.
- W2989194872 created "2019-11-22" @default.
- W2989194872 creator A5029772342 @default.
- W2989194872 date "2019-11-11" @default.
- W2989194872 modified "2023-09-26" @default.
- W2989194872 title "Division of labor in metabolic regulation by transcription, translation, acetylation and phosphorylation" @default.
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