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- W2989199501 abstract "Introduction and objectives There is evidence of a protective effect of prenatal long-chain (LC) n-3 polyunsaturated fatty acids (PUFA) on asthma risk, but longitudinal data on the relation between dietary intake in childhood and asthma risk are scarce. We aimed to investigate whether a higher intake of LC n-3 PUFA from fish in childhood is associated with a lower risk of incident asthma. Methods In the Avon Longitudinal Study of Parents and Children, dietary intake of LC n-3 PUFA from fish, comprised of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), was estimated by food frequency questionnaire at 7 years of age. Amongst children free of doctor-diagnosed asthma at 7 years, we defined incident asthma as new doctor-diagnosed cases occurring between 7 and 14 years of age. We used logistic regression to test the association between quartiles of LC n-3 PUFA intake and incident asthma, adjusted for potential confounders. We stratified the analyses by fatty acid desaturase (FADS) genotype to explore potential effect modification; a single nucleotide polymorphism, rs1535, predicts plasma levels of LC n-3 PUFA (G allele carriers having lower levels). Results We identified 393 (8.64%) new cases of doctor-diagnosed asthma in 4,551 children included in this analysis. There was no statistically significant association between intake of LC n-3 PUFA from fish and incident asthma overall (table). However, when stratified by FADS genotype, a strong inverse association was seen amongst children who carried the minor G allele, with evidence of a dose-response (P=0.002), but no inverse association was observed amongst those who were homozygous for the major A allele (P-interaction=0.007). Similar effect modification was observed for intake of EPA (P-interaction=0.04) and DHA (P-interaction=0.008). Conclusions Higher intake of LC n-3 PUFA from fish in childhood is associated with a lower risk of incident asthma, but only in children with a FADS gene variant associated with the poorer endogenous synthesis of EPA and DHA." @default.
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- W2989199501 date "2019-11-12" @default.
- W2989199501 modified "2023-09-26" @default.
- W2989199501 title "S131 Dietary intake of long-chain n-3 polyunsaturated fatty acids and risk of childhood asthma" @default.
- W2989199501 doi "https://doi.org/10.1136/thorax-2019-btsabstracts2019.137" @default.
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