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- W2989201230 abstract "We have reported that chymotrypsin B (CtrB) is not just a digestive enzyme but is also stored in lyso- somes. Herein, we demonstrated a broad distribution of CtrB and explored the involvement of CtrB in apoptosis. Exposure of RH-35 cells to H2O2 or palmitate induced the redistribution of lysosomal CtrB into the cytoplasm as a result of lysosomal membrane permeabilization (LMP). Suppression of CtrB significantly blocked apoptosis, while overexpression of CtrB sensitized apoptosis markedly. CtrB could cleave Bid under neutral conditions. In RH-35 cells with Bid silenced, apoptosis induced by CtrB protein was attenuated, suggesting that CtrB mediates apoptosis of RH-35 cells mainly through processing Bid. Our data also suggest that LMP occurs earlier than mitochondrial outer membrane permeabilization; Bid activation initiated by caspase-8 might be reinforced by CtrB in consequence of LMP, which causes a positive feedback loop leading to the accumulation of tBid, and results in lysosome- and mito- chondrion-dependent apoptosis." @default.
- W2989201230 created "2019-11-22" @default.
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- W2989201230 date "2010-01-01" @default.
- W2989201230 modified "2023-09-27" @default.
- W2989201230 title "Lysosomal chymotrypsin B potentiates apoptosis via cleavage of Bid" @default.
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