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• W2989210532 endingPage "103427" @default.
• W2989210532 startingPage "103427" @default.
• W2989210532 abstract "New tailored copper(II)–based intercalating complexes [Cu(L1)2] (1) and [Cu(L2)2] (2) were synthesized from Schiff base scaffold HL1 and HL2(E)-4-(2-((2-hydroxy-3-methoxybenzylidene)amino)ethyl)benzenesulfonamide and (E)-4-(2-((2-hydroxybenzylidene)amino)ethyl)benzenesulfonamide, respectively. The structure elucidation of complexes 1 and 2 was carried out by employing various spectroscopic techniques viz., FT–IR, UV–vis, ESI–MS, EPR and single X–ray crystal diffraction studies. The complexes 1 and 2 were crystallized in monoclinic P21/n and triclinic P–1 space group, respectively possessing square planar geometry around Cu(II) coordinated with N,O–donor Schiff base ligands. An analysis of Hirshfeld surfaces of complexes 1 and 2 were performed to ascertain different intra and intermolecular non–covalent interactions (H–bonding, CH⋯ π etc.) responsible for the stabilization of crystal lattices. Calculations based on Density functional theory (B3LYP/DFT), have been carried out to obtain energies of Frontier molecular orbitals. Comparative in vitro binding profile of complexes 1 and 2 with ct–DNA was evaluated employing various biophysical techniques viz., UV–vis, fluorescence, circular dichroism and cyclic voltammetry which suggested non-covalent intercalative binding mode with more avid binding propensity of complex 1 compared to complex 2. The cleavage experiments of complex 1 was performed by gel electrophoretic assay which revealed efficient cleavage mediated via oxidative pathway. Furthermore, topoisomerase I enzymatic activity of complex 1 was carried out employing gel electrophoretic assay which demonstrated significant inhibitory effects at a low concentration of 25 µM. The cytotoxic potential of complex 1 was analyzed by SRB assay on a panel of selected human cancer cell lines which revealed selective activity for MCF-7 (breast cancer) cell line with GI50 = 16.21 µg/ml." @default.
• W2989210532 created "2019-11-22" @default.
• W2989210532 creator A5009713147 @default.
• W2989210532 creator A5049143428 @default.
• W2989210532 creator A5049742544 @default.
• W2989210532 creator A5084938854 @default.
• W2989210532 date "2020-01-01" @default.
• W2989210532 modified "2023-10-17" @default.
• W2989210532 title "Structure elucidation {spectroscopic, single crystal X-ray diffraction and computational DFT studies} of new tailored benzenesulfonamide derived Schiff base copper(II) intercalating complexes: Comprehensive biological profile {DNA binding, pBR322 DNA cleavage, Topo I inhibition and cytotoxic activity}" @default.
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• W2989210532 doi "https://doi.org/10.1016/j.bioorg.2019.103427" @default.
• W2989210532 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31735357" @default.
• W2989210532 hasPublicationYear "2020" @default.
• W2989210532 type Work @default.

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