FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2989241662> ?p ?o ?g. }

• W2989241662 endingPage "949" @default.
• W2989241662 startingPage "939" @default.
• W2989241662 abstract "Traumatic brain injury (TBI) is known to cause short- and long-term synaptic changes in the brain, possibly underlying downstream cognitive impairments. Neuronal levels of neurogranin, a calcium-sensitive calmodulin-binding protein essential for synaptic plasticity and postsynaptic signaling, are correlated with cognitive function. This study aims to understand the effect of TBI on neurogranin by characterizing changes in protein expression at various time points after injury. Adult, male rats were subjected to either controlled cortical impact (CCI) or control surgery. Expression of neurogranin and post-synaptic density 95 (PSD-95) were evaluated by Western blot in the cortex and hippocampus at 24 h and 1, 2, and 4 weeks post-injury. We hypothesized that CCI reduces neurogranin levels in the cortex and hippocampus, and demonstrate different expression patterns from PSD-95. Neurogranin levels were reduced in the ipsilateral cortex and hippocampus up to 2 weeks after injury but recovered to sham levels by 4 weeks. The contralateral cortex and hippocampus were relatively resistant to changes in neurogranin expression post-injury. Qualitative immunohistochemical assessment corroborated the immunoblot findings. Particularly, the pericontusional cortex and ipsilateral Cornu Ammonis (CA)3 region showed marked reduction in immunoreactivity. PSD-95 demonstrated similar expression patterns to neurogranin in the cortex; however, in the hippocampus, protein expression was increased compared with sham at the 2 and 4 week time points. Our results indicate that CCI lowers neurogranin expression with temporal and regional specificity and that this occurs independently of dendritic loss. Further understanding of the role of neurogranin in synaptic biology after TBI will elucidate pathological mechanisms contributing to cognitive dysfunction." @default.
• W2989241662 created "2019-11-22" @default.
• W2989241662 creator A5018477607 @default.
• W2989241662 creator A5022978233 @default.
• W2989241662 creator A5034033533 @default.
• W2989241662 creator A5043326654 @default.
• W2989241662 creator A5043358402 @default.
• W2989241662 creator A5081876521 @default.
• W2989241662 date "2020-04-01" @default.
• W2989241662 modified "2023-10-18" @default.
• W2989241662 title "Neurogranin Protein Expression Is Reduced after Controlled Cortical Impact in Rats" @default.
• W2989241662 cites W1487695731 @default.
• W2989241662 cites W1535134773 @default.
• W2989241662 cites W1575693343 @default.
• W2989241662 cites W1619886377 @default.
• W2989241662 cites W1704662995 @default.
• W2989241662 cites W1804151482 @default.
• W2989241662 cites W1923767489 @default.
• W2989241662 cites W1964169664 @default.
• W2989241662 cites W1965548367 @default.
• W2989241662 cites W1974560467 @default.
• W2989241662 cites W1983759041 @default.
• W2989241662 cites W1984704475 @default.
• W2989241662 cites W1989824843 @default.
• W2989241662 cites W1991356941 @default.
• W2989241662 cites W2003138178 @default.
• W2989241662 cites W2004007133 @default.
• W2989241662 cites W2008030217 @default.
• W2989241662 cites W2010804806 @default.
• W2989241662 cites W2011348649 @default.
• W2989241662 cites W2012620766 @default.
• W2989241662 cites W2013969462 @default.
• W2989241662 cites W2014567150 @default.
• W2989241662 cites W2016535081 @default.
• W2989241662 cites W2018359045 @default.
• W2989241662 cites W2019544787 @default.
• W2989241662 cites W2028084973 @default.
• W2989241662 cites W2029015906 @default.
• W2989241662 cites W2045732157 @default.
• W2989241662 cites W2059785780 @default.
• W2989241662 cites W2066159876 @default.
• W2989241662 cites W2067324713 @default.
• W2989241662 cites W2073595496 @default.
• W2989241662 cites W2076664539 @default.
• W2989241662 cites W2077812845 @default.
• W2989241662 cites W2078661875 @default.
• W2989241662 cites W2079156156 @default.
• W2989241662 cites W2081113831 @default.
• W2989241662 cites W2083203380 @default.
• W2989241662 cites W2094188444 @default.
• W2989241662 cites W2094383620 @default.
• W2989241662 cites W2109837753 @default.
• W2989241662 cites W2117932753 @default.
• W2989241662 cites W2147961047 @default.
• W2989241662 cites W2161262899 @default.
• W2989241662 cites W2205427262 @default.
• W2989241662 cites W2475027332 @default.
• W2989241662 cites W2555553582 @default.
• W2989241662 cites W2754861217 @default.
• W2989241662 cites W2758120807 @default.
• W2989241662 cites W2770452554 @default.
• W2989241662 cites W2807325071 @default.
• W2989241662 cites W2914769084 @default.
• W2989241662 cites W2943724291 @default.
• W2989241662 cites W310871232 @default.
• W2989241662 cites W379165252 @default.
• W2989241662 cites W625230187 @default.
• W2989241662 doi "https://doi.org/10.1089/neu.2019.6759" @default.
• W2989241662 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7175627" @default.
• W2989241662 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31691647" @default.
• W2989241662 hasPublicationYear "2020" @default.
• W2989241662 type Work @default.
• W2989241662 sameAs 2989241662 @default.
• W2989241662 citedByCount "11" @default.
• W2989241662 countsByYear W29892416622020 @default.
• W2989241662 countsByYear W29892416622021 @default.
• W2989241662 countsByYear W29892416622022 @default.
• W2989241662 countsByYear W29892416622023 @default.
• W2989241662 crossrefType "journal-article" @default.
• W2989241662 hasAuthorship W2989241662A5018477607 @default.
• W2989241662 hasAuthorship W2989241662A5022978233 @default.
• W2989241662 hasAuthorship W2989241662A5034033533 @default.
• W2989241662 hasAuthorship W2989241662A5043326654 @default.
• W2989241662 hasAuthorship W2989241662A5043358402 @default.
• W2989241662 hasAuthorship W2989241662A5081876521 @default.
• W2989241662 hasBestOaLocation W29892416622 @default.
• W2989241662 hasConcept C11960822 @default.
• W2989241662 hasConcept C126322002 @default.
• W2989241662 hasConcept C134018914 @default.
• W2989241662 hasConcept C15744967 @default.
• W2989241662 hasConcept C169760540 @default.
• W2989241662 hasConcept C169900460 @default.
• W2989241662 hasConcept C170493617 @default.
• W2989241662 hasConcept C195794163 @default.
• W2989241662 hasConcept C204232928 @default.
• W2989241662 hasConcept C2777209535 @default.
• W2989241662 hasConcept C2777348757 @default.
• W2989241662 hasConcept C2780748493 @default.

• next