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- W2989268307 abstract "The authors examined the hypothesis that dopaminergic inhibition of prolactin release is coupled to modulation of cellular calcium flux. Dispersed female rat pituitary cells were prelabeled in /sup 45/Ca/sup 2 +/ and perifused to determine simultaneously fractional calcium efflux and prolactin release, as stimulated by maitotoxin, a calcium channel activator. The integrated response of each parameter to 5 ng/ml maitotoxin was obtained in individual perifusion columns in the absence or presence of various concentrations of dopamine. Maitotoxin-stimulated calcium efflux was suppressed by dopamine concentrations of 0.01 ..mu..M and greater and achieved a maximal effect at approx.0.1 ..mu..M, at which calcium efflux was reduced by 50%. Maitotoxin-stimulated prolactin release was inhibited by 0.03 ..mu..M dopamine and greater concentrations, and at a concentration of approx.10.0 ..mu..M dopamine the effect became maximal at approx.85% suppression. Haloperidol (0.1 ..mu..M) blocked the effects of 0.1 ..mu..M dopamine on both parameters. Simultaneous suppression of maitotoxin-stimulated calcium efflux and prolactin release by concentrations of dopamine within the nonomolar range suggests that dopamine receptor activation is negatively coupled to modulation of calcium flux in the physiological regulation of prolactin secretion." @default.
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- W2989268307 date "1986-06-01" @default.
- W2989268307 modified "2023-09-24" @default.
- W2989268307 title "Dopamine inhibits maitotoxin-stimulated pituitary /sup 45/Ca/sup 2 +/ efflux and prolactin release" @default.
- W2989268307 hasPublicationYear "1986" @default.
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