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- W2989272316 abstract "Herein, a novel type of multifunctional magnetic nanoparticles with dual thermal and pH-responsive behavior was fabricated as the carrier for delivery of doxorubicin (DOX). Fe3O4@SiO2 magnetic nanoparticles, were grafted with polymer brushes consisting of poly (NIPAM-co-GMA) (PNG) chains via surface initiated reversible addition-fragmentation chain transfer (SI-RAFT) polymerization. The polymer brushes were then modified with hydrazine groups as DOX binding sites. The prepared multifunctional magnetic nanoparticles were characterized by FT-IR, 1H NMR, XPS, TGA, DLS, VSM, GPC, TEM, and XRD analysis. The in vitro drug release of the multifunctional magnetic nanoparticles was examined at 37 °C (above LCST) and 25 °C (below LCST) in different pH media and exhibited excellent pH- and thermo-sensitive behavior. The results show that the Fe3O4@SiO2@PNG-Hy fabricated via SI-RAFT polymerization is a viable candidate material for tumor treatment studies." @default.
- W2989272316 created "2019-11-22" @default.
- W2989272316 creator A5067403563 @default.
- W2989272316 creator A5080329256 @default.
- W2989272316 date "2020-03-01" @default.
- W2989272316 modified "2023-10-03" @default.
- W2989272316 title "pH and thermal dual-responsive poly(NIPAM-co-GMA)-coated magnetic nanoparticles via surface-initiated RAFT polymerization for controlled drug delivery" @default.
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- W2989272316 doi "https://doi.org/10.1016/j.msec.2019.110418" @default.
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