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• W2989291275 abstract "During the later stages of lung development, two types of pneumocytes, cuboidal type II (AECII) and flattened type I (AECI) alveolar epithelial cells, form distal lung saccules. Here we highlight how fibroblasts-expressing MAP-microtubule affinity regulating kinase 1 (Mark1) are required for distal lung sacculation. In Mark1 knockout (KO) mice, distal sacculation and AECI flattening are significantly impaired. Fetal epithelial cells generate alveolar organoids and differentiate into pneumocytes when cocultured with fibroblasts. However, the size of organoids decreased and AECI flattening was impaired in the presence of Mark1 KO fibroblasts. In Mark1 KO fibroblasts themselves, cilia formation and the Hedgehog pathway were suppressed, resulting in the loss of type I collagen expression. The addition of type I collagen restored AECI flattening in organoids-cocultured with Mark1 KO fibroblasts and rescued the decreased size of organoids. Mathematical modeling of distal lung sacculation supports the view that AECI flattening is necessary for properly formed saccule-like structures. These results suggest that Mark1-mediated fibroblast activation induces AECI flattening and thereby regulates distal lung sacculation." @default.
• W2989291275 created "2019-11-22" @default.
• W2989291275 creator A5013530666 @default.
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• W2989291275 date "2019-01-01" @default.
• W2989291275 modified "2023-10-11" @default.
• W2989291275 title "Mark1 regulates distal airspace expansion through type I pneumocyte flattening in lung development" @default.
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• W2989291275 doi "https://doi.org/10.1242/jcs.235556" @default.
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