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- W2989300908 abstract "Abstract Efforts to develop a safe, effective, and affordable dengue vaccine have focused on providing simultaneous immunity against all four serotypes of the dengue virus (DENV). In the current study, Salmonella Typhimurium (ST) lysed by gene E activation was genetically constructed to deliver the envelope protein domain III (EDIII) of all four serotypes of DENV using a foreign antigen delivery and expression vector, pJHL184. Each DENV-EDIII protein expressed in the constructed strain was validated by immunoblot analysis. To assess the immunogenicity and protective efficacy of the constructs against dengue infection, BALB/c mice were injected once orally with either the individual ST-EDIII constructs or a mix of all four ST-EDIII constructs followed by intramuscular administration of the purified EDIII protein. Significantly elevated titers of EDIII-specific IgG, IgG1, and IgG2a were observed in the immunized mice (P" @default.
- W2989300908 created "2019-11-22" @default.
- W2989300908 creator A5015511808 @default.
- W2989300908 creator A5022057151 @default.
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- W2989300908 date "2020-01-01" @default.
- W2989300908 modified "2023-09-24" @default.
- W2989300908 title "Construction of a novel tetravalent dengue vaccine with a Salmonella Typhimurium bacterial ghost and evaluation of its immunogenicity and protective efficacy using a murine model" @default.
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- W2989300908 doi "https://doi.org/10.1016/j.vaccine.2019.10.075" @default.
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