Matches in SemOpenAlex for { <https://semopenalex.org/work/W2989340324> ?p ?o ?g. }
- W2989340324 endingPage "1346" @default.
- W2989340324 startingPage "1329" @default.
- W2989340324 abstract "Abstract Cells of the oligodendrocyte (OLG) lineage engage in highly motile behaviors that are crucial for effective central nervous system (CNS) myelination. These behaviors include the guided migration of OLG progenitor cells (OPCs), the surveying of local environments by cellular processes extending from differentiating and pre‐myelinating OLGs, and during the process of active myelin wrapping, the forward movement of the leading edge of the myelin sheath's inner tongue along the axon. Almost all of these motile behaviors are driven by actin cytoskeletal dynamics initiated within a lamellipodial structure that is located at the tip of cellular OLG/OPC processes and is structurally as well as functionally similar to the neuronal growth cone. Accordingly, coordinated stoichiometries of actin filament (F‐actin) assembly and disassembly at these OLG/OPC growth cones have been implicated in directing process outgrowth and guidance, and the initiation of myelination. Nonetheless, the functional importance of the OLG/OPC growth cone still remains to be fully understood, and, as a unique aspect of actin cytoskeletal dynamics, F‐actin depolymerization and disassembly start to predominate at the transition from myelination initiation to myelin wrapping. This review provides an overview of the current knowledge about OLG/OPC growth cones, and it proposes a model in which actin cytoskeletal dynamics in OLG/OPC growth cones are a main driver for morphological transformations and motile behaviors. Remarkably, these activities, at least at the later stages of OLG maturation, may be regulated independently from the transcriptional gene expression changes typically associated with CNS myelination." @default.
- W2989340324 created "2019-11-22" @default.
- W2989340324 creator A5024125995 @default.
- W2989340324 creator A5030452401 @default.
- W2989340324 creator A5032202964 @default.
- W2989340324 creator A5039126276 @default.
- W2989340324 date "2019-11-07" @default.
- W2989340324 modified "2023-10-01" @default.
- W2989340324 title "The oligodendrocyte growth cone and its actin cytoskeleton: A fundamental element for progenitor cell migration and CNS myelination" @default.
- W2989340324 cites W1479891216 @default.
- W2989340324 cites W1489223626 @default.
- W2989340324 cites W1509726604 @default.
- W2989340324 cites W1540043927 @default.
- W2989340324 cites W1543519398 @default.
- W2989340324 cites W1576900460 @default.
- W2989340324 cites W1580040847 @default.
- W2989340324 cites W1604048375 @default.
- W2989340324 cites W1741685909 @default.
- W2989340324 cites W1789330717 @default.
- W2989340324 cites W1835026554 @default.
- W2989340324 cites W1839988640 @default.
- W2989340324 cites W1901712533 @default.
- W2989340324 cites W1914139737 @default.
- W2989340324 cites W1955394435 @default.
- W2989340324 cites W1957508267 @default.
- W2989340324 cites W1969202645 @default.
- W2989340324 cites W1970538568 @default.
- W2989340324 cites W1971006243 @default.
- W2989340324 cites W1975149361 @default.
- W2989340324 cites W1975719696 @default.
- W2989340324 cites W1976100793 @default.
- W2989340324 cites W1976433348 @default.
- W2989340324 cites W1977669212 @default.
- W2989340324 cites W1978525637 @default.
- W2989340324 cites W1980116218 @default.
- W2989340324 cites W1981107697 @default.
- W2989340324 cites W1983350593 @default.
- W2989340324 cites W1985829219 @default.
- W2989340324 cites W1986094842 @default.
- W2989340324 cites W1990829377 @default.
- W2989340324 cites W1991062406 @default.
- W2989340324 cites W1991155053 @default.
- W2989340324 cites W1994167334 @default.
- W2989340324 cites W1994544597 @default.
- W2989340324 cites W1995954654 @default.
- W2989340324 cites W1996131663 @default.
- W2989340324 cites W1997734809 @default.
- W2989340324 cites W1999708992 @default.
- W2989340324 cites W2001888569 @default.
- W2989340324 cites W2002513784 @default.
- W2989340324 cites W2003468593 @default.
- W2989340324 cites W2004750343 @default.
- W2989340324 cites W2005203145 @default.
- W2989340324 cites W2007660746 @default.
- W2989340324 cites W2008775796 @default.
- W2989340324 cites W2010745787 @default.
- W2989340324 cites W2011470992 @default.
- W2989340324 cites W2012272897 @default.
- W2989340324 cites W2015602829 @default.
- W2989340324 cites W2015686686 @default.
- W2989340324 cites W2017918866 @default.
- W2989340324 cites W2020018859 @default.
- W2989340324 cites W2021311192 @default.
- W2989340324 cites W2022546866 @default.
- W2989340324 cites W2025301878 @default.
- W2989340324 cites W2025339136 @default.
- W2989340324 cites W2025488020 @default.
- W2989340324 cites W2026064166 @default.
- W2989340324 cites W2028939491 @default.
- W2989340324 cites W2029022457 @default.
- W2989340324 cites W2031489662 @default.
- W2989340324 cites W2031733803 @default.
- W2989340324 cites W2032811802 @default.
- W2989340324 cites W2034259975 @default.
- W2989340324 cites W2034614910 @default.
- W2989340324 cites W2034926640 @default.
- W2989340324 cites W2035688930 @default.
- W2989340324 cites W2040085463 @default.
- W2989340324 cites W2041083111 @default.
- W2989340324 cites W2041934535 @default.
- W2989340324 cites W2042270905 @default.
- W2989340324 cites W2042832329 @default.
- W2989340324 cites W2045460359 @default.
- W2989340324 cites W2046716216 @default.
- W2989340324 cites W2048788946 @default.
- W2989340324 cites W2049548683 @default.
- W2989340324 cites W2049811440 @default.
- W2989340324 cites W2050674773 @default.
- W2989340324 cites W2051053924 @default.
- W2989340324 cites W2051758640 @default.
- W2989340324 cites W2054275187 @default.
- W2989340324 cites W2054696265 @default.
- W2989340324 cites W2058358434 @default.
- W2989340324 cites W2059216302 @default.
- W2989340324 cites W2059276463 @default.
- W2989340324 cites W2063011052 @default.
- W2989340324 cites W2063116489 @default.
- W2989340324 cites W2065331372 @default.