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• W2989345674 abstract "Abstract Design of theranostic nanoplatforms represents a major topic for current nanomedicine. Here, the preparation of multifunctional poly(cyclotriphosphazene‐ co ‐polyethylenimine) nanospheres (PNSs) labeled with radionuclide 131 I for single photon emission computed tomography (SPECT) imaging‐guided radiotherapy of tumors is reported. In this work, PNSs are prepared using hexachlorocyclotriphosphazene as a crosslinker to crosslink branched polyethylenimine (PEI) via a nucleophilic substitution reaction, modified with 3‐(4′‐hydroxyphenyl) propionic acid‐OSu (HPAO) for 131 I labeling, and reacted with 1,3‐propane sulfonate (1,3‐PS) to render the particles with antifouling property, followed by acetylation of the remaining surface amines and labeling with 131 I. The acquired PNS.NHAc‐HPAO( 131 I)‐PS particles are well characterized. It is shown that the multifunctional PNSs with an average size of 184 ± 29.3 nm exhibit favorable antifouling properties, high 131 I labeling efficiency (76.05 ± 3.75%), and excellent radiostability and colloidal stability. With these properties owned, the developed PNS.NHAc‐HPAO( 131 I)‐PS spheres enable much more efficient SPECT imaging and radiotherapy of a xenografted tumor model in vivo than the PEI counterpart material (PEI.NHAc‐HPAO( 131 I)‐PS). The developed PNSs may be used as a versatile platform for further development of different forms of nanomedicine for various biomedical applications." @default.
• W2989345674 created "2019-11-22" @default.
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• W2989345674 date "2019-11-07" @default.
• W2989345674 modified "2023-10-18" @default.
• W2989345674 title "¹³¹ I‐Labeled Multifunctional Polyphosphazene Nanospheres for SPECT Imaging‐Guided Radiotherapy of Tumors" @default.
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• W2989345674 doi "https://doi.org/10.1002/adhm.201901299" @default.
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