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- W2989360867 endingPage "1993" @default.
- W2989360867 startingPage "1993" @default.
- W2989360867 abstract "Interleukin-18 (IL-18) is a cytokine that enhances innate and adaptive immune responses. Although there are conflicting reports about the roles of IL-18 in melanoma progression, the clinical relevance of IL-18 expression has not been comprehensively studied. In this study, we investigated IL-18 expression and its correlation with patient survival and immune cell infiltration in melanoma using cancer gene expression data publicly available through various databases. IL18 mRNA expression was found to be significantly lower in melanoma tissues than normal tissues. Kaplan-Meier survival analysis showed that IL18 expression was positively correlated with patient survival. To investigate the possible mechanisms by which IL18 expression increased patient survival, we then assessed the correlation between IL18 expression and immune cell infiltration levels. Infiltration of various immune cells, especially CD8+ T and natural killer (NK) cells, which are cytolytic effector cells, was significantly increased by IL18 expression. Additionally, the expression levels of two cytolytic molecules including perforin and granzyme B were significantly positively correlated with IL18 expression. Collectively, this study provides the first evidence that IL18 expression has prognostic value for melanoma patient survival and is strongly correlated with CD8+ T and NK cell infiltration, suggesting the role of IL-18 as a biomarker for predicting melanoma prognosis." @default.
- W2989360867 created "2019-11-22" @default.
- W2989360867 creator A5035795388 @default.
- W2989360867 creator A5057367224 @default.
- W2989360867 date "2019-11-15" @default.
- W2989360867 modified "2023-10-14" @default.
- W2989360867 title "Interleukin-18 Is a Prognostic Biomarker Correlated with CD8+ T Cell and Natural Killer Cell Infiltration in Skin Cutaneous Melanoma" @default.
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- W2989360867 cites W1512693074 @default.
- W2989360867 cites W1693854039 @default.
- W2989360867 cites W1852344107 @default.
- W2989360867 cites W1971791400 @default.
- W2989360867 cites W1972197089 @default.
- W2989360867 cites W1975109271 @default.
- W2989360867 cites W1977918192 @default.
- W2989360867 cites W1983249148 @default.
- W2989360867 cites W1983548130 @default.
- W2989360867 cites W1985987855 @default.
- W2989360867 cites W1991150724 @default.
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- W2989360867 cites W2011770661 @default.
- W2989360867 cites W2012110635 @default.
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- W2989360867 cites W2023264499 @default.
- W2989360867 cites W2027917855 @default.
- W2989360867 cites W2033917892 @default.
- W2989360867 cites W2037915750 @default.
- W2989360867 cites W2048657818 @default.
- W2989360867 cites W2050209022 @default.
- W2989360867 cites W2065391130 @default.
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- W2989360867 cites W2082668371 @default.
- W2989360867 cites W2096621446 @default.
- W2989360867 cites W2114843025 @default.
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- W2989360867 cites W2125554291 @default.
- W2989360867 cites W2130354176 @default.
- W2989360867 cites W2133790771 @default.
- W2989360867 cites W2139643093 @default.
- W2989360867 cites W2146313292 @default.
- W2989360867 cites W2149441684 @default.
- W2989360867 cites W2149579127 @default.
- W2989360867 cites W2152315800 @default.
- W2989360867 cites W2171831396 @default.
- W2989360867 cites W2177971463 @default.
- W2989360867 cites W2256549280 @default.
- W2989360867 cites W2275678839 @default.
- W2989360867 cites W2279794760 @default.
- W2989360867 cites W2313168486 @default.
- W2989360867 cites W2551371378 @default.
- W2989360867 cites W2560367415 @default.
- W2989360867 cites W2572174216 @default.
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- W2989360867 cites W2607211817 @default.
- W2989360867 cites W2744632602 @default.
- W2989360867 cites W2765224588 @default.
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- W2989360867 cites W2784311950 @default.
- W2989360867 cites W2788142646 @default.
- W2989360867 cites W2791693855 @default.
- W2989360867 cites W2795989238 @default.
- W2989360867 cites W2797943100 @default.
- W2989360867 cites W2889646458 @default.
- W2989360867 cites W2890499629 @default.
- W2989360867 cites W2892951532 @default.
- W2989360867 cites W2901513648 @default.
- W2989360867 cites W2911335821 @default.
- W2989360867 cites W2915822971 @default.
- W2989360867 cites W2930324748 @default.
- W2989360867 cites W2945093047 @default.
- W2989360867 cites W2946657092 @default.
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- W2989360867 doi "https://doi.org/10.3390/jcm8111993" @default.
- W2989360867 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6912818" @default.
- W2989360867 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31731729" @default.
- W2989360867 hasPublicationYear "2019" @default.
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