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- W2989403882 endingPage "5583" @default.
- W2989403882 startingPage "5583" @default.
- W2989403882 abstract "The selectivity of the blood-brain barrier (BBB) is primarily maintained by tight junctions (TJs), which act as gatekeepers of the paracellular space by blocking blood-borne toxins, drugs, and pathogens from entering the brain. The BBB presents a significant challenge in designing neurotherapeutics, so a comprehensive understanding of the TJ architecture can aid in the design of novel therapeutics. Unraveling the intricacies of TJs with conventional experimental techniques alone is challenging, but recently developed computational tools can provide a valuable molecular-level understanding of TJ architecture. We employed the computational methods toolkit to investigate claudin-5, a highly expressed TJ protein at the BBB interface. Our approach started with the prediction of claudin-5 structure, evaluation of stable dimer conformations and nanoscale assemblies, followed by the impact of lipid environments, and posttranslational modifications on these claudin-5 assemblies. These led to the study of TJ pores and barriers and finally understanding of ion and small molecule transport through the TJs. Some of these in silico, molecular-level findings, will need to be corroborated by future experiments. The resulting understanding can be advantageous towards the eventual goal of drug delivery across the BBB. This review provides key insights gleaned from a series of state-of-the-art nanoscale simulations (or computational nanoscopy studies) performed on the TJ architecture." @default.
- W2989403882 created "2019-11-22" @default.
- W2989403882 creator A5029935636 @default.
- W2989403882 creator A5034237670 @default.
- W2989403882 creator A5051264051 @default.
- W2989403882 date "2019-11-08" @default.
- W2989403882 modified "2023-10-16" @default.
- W2989403882 title "Computational Nanoscopy of Tight Junctions at the Blood–Brain Barrier Interface" @default.
- W2989403882 cites W1031578623 @default.
- W2989403882 cites W1133957130 @default.
- W2989403882 cites W128151115 @default.
- W2989403882 cites W1498982214 @default.
- W2989403882 cites W1500442720 @default.
- W2989403882 cites W1513150088 @default.
- W2989403882 cites W1530044518 @default.
- W2989403882 cites W1554042779 @default.
- W2989403882 cites W1560983797 @default.
- W2989403882 cites W1589010135 @default.
- W2989403882 cites W1606934029 @default.
- W2989403882 cites W1796054280 @default.
- W2989403882 cites W1803102843 @default.
- W2989403882 cites W1827465345 @default.
- W2989403882 cites W1888485834 @default.
- W2989403882 cites W1926327739 @default.
- W2989403882 cites W1965548701 @default.
- W2989403882 cites W1966816931 @default.
- W2989403882 cites W1971622557 @default.
- W2989403882 cites W1973544766 @default.
- W2989403882 cites W1974635207 @default.
- W2989403882 cites W1975421091 @default.
- W2989403882 cites W1976369464 @default.
- W2989403882 cites W1977594835 @default.
- W2989403882 cites W1978308218 @default.
- W2989403882 cites W1978656738 @default.
- W2989403882 cites W1978730075 @default.
- W2989403882 cites W1979547026 @default.
- W2989403882 cites W1980374511 @default.
- W2989403882 cites W1981264193 @default.
- W2989403882 cites W1981760537 @default.
- W2989403882 cites W1985911976 @default.
- W2989403882 cites W1986482900 @default.
- W2989403882 cites W1986986500 @default.
- W2989403882 cites W1987134040 @default.
- W2989403882 cites W1988474837 @default.
- W2989403882 cites W1989855778 @default.
- W2989403882 cites W1990689226 @default.
- W2989403882 cites W1990771438 @default.
- W2989403882 cites W1992909182 @default.
- W2989403882 cites W1993177346 @default.
- W2989403882 cites W1993729684 @default.
- W2989403882 cites W1994837626 @default.
- W2989403882 cites W1995766554 @default.
- W2989403882 cites W1996719014 @default.
- W2989403882 cites W1999346012 @default.
- W2989403882 cites W1999613945 @default.
- W2989403882 cites W1999977488 @default.
- W2989403882 cites W2000422049 @default.
- W2989403882 cites W2002233682 @default.
- W2989403882 cites W2003564623 @default.
- W2989403882 cites W2007070530 @default.
- W2989403882 cites W2007490029 @default.
- W2989403882 cites W2007616467 @default.
- W2989403882 cites W2010375822 @default.
- W2989403882 cites W201125491 @default.
- W2989403882 cites W2011356699 @default.
- W2989403882 cites W2013652494 @default.
- W2989403882 cites W2015214828 @default.
- W2989403882 cites W2019417484 @default.
- W2989403882 cites W2019691413 @default.
- W2989403882 cites W2020216238 @default.
- W2989403882 cites W2021520922 @default.
- W2989403882 cites W2022219701 @default.
- W2989403882 cites W2023104359 @default.
- W2989403882 cites W2023490488 @default.
- W2989403882 cites W2023980306 @default.
- W2989403882 cites W2024311391 @default.
- W2989403882 cites W2027005863 @default.
- W2989403882 cites W2027408247 @default.
- W2989403882 cites W2028267884 @default.
- W2989403882 cites W2029667189 @default.
- W2989403882 cites W2033140618 @default.
- W2989403882 cites W2034512365 @default.
- W2989403882 cites W2034626424 @default.
- W2989403882 cites W2036108598 @default.
- W2989403882 cites W2036862423 @default.
- W2989403882 cites W2037312364 @default.
- W2989403882 cites W2039181331 @default.
- W2989403882 cites W2039350725 @default.
- W2989403882 cites W2040022930 @default.
- W2989403882 cites W2041158750 @default.
- W2989403882 cites W2041848964 @default.
- W2989403882 cites W2043901383 @default.
- W2989403882 cites W2048893204 @default.
- W2989403882 cites W2051381895 @default.
- W2989403882 cites W2051864856 @default.
- W2989403882 cites W2053538195 @default.
- W2989403882 cites W2054018316 @default.
- W2989403882 cites W2057806291 @default.