FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2989404679> ?p ?o ?g. }

• W2989404679 endingPage "39" @default.
• W2989404679 startingPage "39" @default.
• W2989404679 abstract "Among the aortic valve diseases, the bicuspid aortic valve (BAV) occurs when the aortic valve has two leaflets (cusps), rather than three, and represents the most common form of congenital cardiac malformation, affecting 1–2% of the population. Despite recent advances, the etiology of BAV is poorly understood. We have recently shown that Krox20 is expressed in endothelial and cardiac neural crest derivatives that normally contribute to aortic valve development and that lack of Krox20 in these cells leads to aortic valve defects including partially penetrant BAV formation. Dysregulated expression of endothelial nitric oxide synthase (Nos3) is associated with BAV. To investigate the relationship between Krox20 and Nos3 during aortic valve development, we performed inter-genetic cross. While single heterozygous mice had normal valve formation, the compound Krox20+/−;Nos3+/− mice had BAV malformations displaying an in vivo genetic interaction between these genes for normal valve morphogenesis. Moreover, in vivo and in vitro experiments demonstrate that Krox20 directly binds to Nos3 proximal promoter to activate its expression. Our data suggests that Krox20 is a regulator of nitric oxide in endothelial-derived cells in the development of the aortic valve and concludes on the interaction of Krox20 and Nos3 in BAV formation." @default.
• W2989404679 created "2019-11-22" @default.
• W2989404679 creator A5035990355 @default.
• W2989404679 creator A5043531075 @default.
• W2989404679 creator A5055320854 @default.
• W2989404679 creator A5078680235 @default.
• W2989404679 date "2019-11-02" @default.
• W2989404679 modified "2023-10-18" @default.
• W2989404679 title "Krox20 Regulates Endothelial Nitric Oxide Signaling in Aortic Valve Development and Disease" @default.
• W2989404679 cites W1710900461 @default.
• W2989404679 cites W1824991881 @default.
• W2989404679 cites W1978312295 @default.
• W2989404679 cites W1978373243 @default.
• W2989404679 cites W1982012141 @default.
• W2989404679 cites W1982459813 @default.
• W2989404679 cites W1983618726 @default.
• W2989404679 cites W1987650867 @default.
• W2989404679 cites W1993139519 @default.
• W2989404679 cites W2005893713 @default.
• W2989404679 cites W2012517517 @default.
• W2989404679 cites W2021418635 @default.
• W2989404679 cites W2022348836 @default.
• W2989404679 cites W2050374121 @default.
• W2989404679 cites W2055614967 @default.
• W2989404679 cites W2076890216 @default.
• W2989404679 cites W2081008365 @default.
• W2989404679 cites W2089662907 @default.
• W2989404679 cites W2091499945 @default.
• W2989404679 cites W2107388688 @default.
• W2989404679 cites W2112837796 @default.
• W2989404679 cites W2113215255 @default.
• W2989404679 cites W2115053071 @default.
• W2989404679 cites W2123115029 @default.
• W2989404679 cites W2124185664 @default.
• W2989404679 cites W2125315792 @default.
• W2989404679 cites W2125727551 @default.
• W2989404679 cites W2126618234 @default.
• W2989404679 cites W2158378290 @default.
• W2989404679 cites W2162452658 @default.
• W2989404679 cites W2171108436 @default.
• W2989404679 cites W2281664039 @default.
• W2989404679 cites W2327791930 @default.
• W2989404679 cites W2612440230 @default.
• W2989404679 cites W2770940524 @default.
• W2989404679 cites W2805535824 @default.
• W2989404679 cites W2809116611 @default.
• W2989404679 cites W2810440784 @default.
• W2989404679 cites W2891682774 @default.
• W2989404679 cites W2900795735 @default.
• W2989404679 cites W1966412599 @default.
• W2989404679 doi "https://doi.org/10.3390/jcdd6040039" @default.
• W2989404679 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6955692" @default.
• W2989404679 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31684048" @default.
• W2989404679 hasPublicationYear "2019" @default.
• W2989404679 type Work @default.
• W2989404679 sameAs 2989404679 @default.
• W2989404679 citedByCount "6" @default.
• W2989404679 countsByYear W29894046792020 @default.
• W2989404679 countsByYear W29894046792021 @default.
• W2989404679 countsByYear W29894046792022 @default.
• W2989404679 countsByYear W29894046792023 @default.
• W2989404679 crossrefType "journal-article" @default.
• W2989404679 hasAuthorship W2989404679A5035990355 @default.
• W2989404679 hasAuthorship W2989404679A5043531075 @default.
• W2989404679 hasAuthorship W2989404679A5055320854 @default.
• W2989404679 hasAuthorship W2989404679A5078680235 @default.
• W2989404679 hasBestOaLocation W29894046791 @default.
• W2989404679 hasConcept C104317684 @default.
• W2989404679 hasConcept C126322002 @default.
• W2989404679 hasConcept C126749454 @default.
• W2989404679 hasConcept C134018914 @default.
• W2989404679 hasConcept C2780714102 @default.
• W2989404679 hasConcept C2781355080 @default.
• W2989404679 hasConcept C519581460 @default.
• W2989404679 hasConcept C54355233 @default.
• W2989404679 hasConcept C71924100 @default.
• W2989404679 hasConcept C86803240 @default.
• W2989404679 hasConcept C95444343 @default.
• W2989404679 hasConceptScore W2989404679C104317684 @default.
• W2989404679 hasConceptScore W2989404679C126322002 @default.
• W2989404679 hasConceptScore W2989404679C126749454 @default.
• W2989404679 hasConceptScore W2989404679C134018914 @default.
• W2989404679 hasConceptScore W2989404679C2780714102 @default.
• W2989404679 hasConceptScore W2989404679C2781355080 @default.
• W2989404679 hasConceptScore W2989404679C519581460 @default.
• W2989404679 hasConceptScore W2989404679C54355233 @default.
• W2989404679 hasConceptScore W2989404679C71924100 @default.
• W2989404679 hasConceptScore W2989404679C86803240 @default.
• W2989404679 hasConceptScore W2989404679C95444343 @default.
• W2989404679 hasFunder F4320309713 @default.
• W2989404679 hasIssue "4" @default.
• W2989404679 hasLocation W29894046791 @default.
• W2989404679 hasLocation W29894046792 @default.
• W2989404679 hasLocation W29894046793 @default.
• W2989404679 hasLocation W29894046794 @default.
• W2989404679 hasLocation W29894046795 @default.
• W2989404679 hasLocation W29894046796 @default.
• W2989404679 hasLocation W29894046797 @default.

• next