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- W2989445493 endingPage "1922" @default.
- W2989445493 startingPage "1922" @default.
- W2989445493 abstract "The outcome of pancreatic cancer is poor, with a 9% 5-year survival rate. Current treatment recommendations in the 10%–20% of patients who present with resectable disease support upfront resection followed by adjuvant therapy. Until now, only early complete surgical (R0) resection and adjuvant chemotherapy (AC) with either FOLFIRINOX (5-fluorouracil, leucovorin, irinotecan, and oxaliplatin) or nab-paclitaxel plus gemcitabine have been shown to prolong the survival. However, up to 30% of patients do not receive adjuvant therapy because of the development of early recurrence, postoperative complications, comorbidities, and reduced performance status. The aims of neoadjuvant chemotherapy (NAC) are to identify rapidly progressing patients to avoid futile surgery, eliminate micrometastases, increase the feasibility of R0 resection, and ensure the completion of multimodal treatment. Neoadjuvant treatments are effective, but there is no consensus on their use in resectable pancreatic cancer (RPC) because of its lack of a survival benefit over adjuvant therapy. In this review, we analyze the advantages and disadvantages of the two therapeutic approaches in RPC. We need studies that compare the two approaches and can identify the appropriate sequence of adjuvant therapy after neoadjuvant treatment and surgery." @default.
- W2989445493 created "2019-11-22" @default.
- W2989445493 creator A5045260424 @default.
- W2989445493 creator A5064254445 @default.
- W2989445493 date "2019-11-08" @default.
- W2989445493 modified "2023-09-30" @default.
- W2989445493 title "Are We Sure that Adjuvant Chemotherapy is the Best Approach for Resectable Pancreatic Cancer? Are We in the Era of Neoadjuvant Treatment? A Review of Current Literature" @default.
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- W2989445493 doi "https://doi.org/10.3390/jcm8111922" @default.
- W2989445493 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6912693" @default.
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- W2989445493 hasPublicationYear "2019" @default.
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