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- W2989449197 endingPage "109625" @default.
- W2989449197 startingPage "109625" @default.
- W2989449197 abstract "Unprecedented efficacy of chimeric antigen receptor (CAR) T cell therapy in the treatment of hematologic malignancies brings new hope for patients with many cancer types including solid tumors. However, the challenges for CAR-T cell therapy in eradicating solid tumors are immense. To overcome these seemingly intractable hurdles, more “powerful” CAR-T cells with enhanced antitumor efficacy are required. Emerging data support that the anti-tumor activity of CAR-T cells can be enhanced significantly without evident toxicity through simultaneous PD-1 disruption by genome editing. This review focuses on the current progress of PD-1 gene disrupted CAR-T cells in cancer therapy. Here we discuss key rationales for this new combination strategy and summarize the available pre-clinical studies. An update is provided on human clinical studies and available registered cancer clinical trials using CAR-T cells with PD-1 disruption. Future prospects and challenges are also discussed." @default.
- W2989449197 created "2019-11-22" @default.
- W2989449197 creator A5001543539 @default.
- W2989449197 creator A5033951182 @default.
- W2989449197 creator A5058894140 @default.
- W2989449197 creator A5059585715 @default.
- W2989449197 creator A5078205294 @default.
- W2989449197 creator A5090323563 @default.
- W2989449197 date "2020-01-01" @default.
- W2989449197 modified "2023-10-18" @default.
- W2989449197 title "PD-1 disrupted CAR-T cells in the treatment of solid tumors: Promises and challenges" @default.
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