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• W2989451198 startingPage "1027" @default.
• W2989451198 abstract "Abstract Heat shock proteins (HSPs), a large group of highly evolutionary conserved proteins, are considered to be main elements of the cellular proteoprotection system. HSPs are encoded by genes activated during the exposure of cells to proteotoxic factors, as well as by genes that are expressed constitutively under physiological conditions. HSPs, having properties of molecular chaperones, are involved in controlling/modulation of multiple cellular and physiological processes. In the presented review, we summarize the current knowledge on HSPs in the biology of epidermis, the outer skin layer composed of stratified squamous epithelium. This tissue has a vital barrier function preventing from dehydratation due to passive diffusion of water out of the skin, and protecting from infection and other environmental insults. We focused on HSPB1 (HSP27), HSPA1 (HSP70), HSPA2, and HSPC (HSP90), because only these HSPs have been studied in the context of physiology and pathophysiology of the epidermis. The analysis of literature data shows that HSPB1 plays a role in the regulation of final steps of keratinization; HSPA1 is involved in the cytoprotection, HSPA2 contributes to the early steps of keratinocyte differentiation, while HSPC is essential in the re-epithelialization process. Since HSPs have diverse functions in various types of somatic tissues, in spite of multiple investigations, open questions still remain about detailed roles of a particular HSP isoform in the biology of epidermal keratinocytes." @default.
• W2989451198 created "2019-11-22" @default.
• W2989451198 creator A5006522507 @default.
• W2989451198 creator A5026039814 @default.
• W2989451198 creator A5052744662 @default.
• W2989451198 creator A5073675969 @default.
• W2989451198 date "2019-11-01" @default.
• W2989451198 modified "2023-10-17" @default.
• W2989451198 title "Heat shock proteins in the physiology and pathophysiology of epidermal keratinocytes" @default.
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