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• W2989455730 endingPage "25" @default.
• W2989455730 startingPage "3" @default.
• W2989455730 abstract "Abstract The term “propagon” is used to define proteins that may transmit misfolding in vitro, in tissues or in organisms. Among propagons, misfolded tau is thought to be involved in the pathogenic mechanisms of various “tauopathies” that include Alzheimer's disease, progressive supranuclear palsy, and argyrophilic grain disease. Here, we review the available data in the literature and point out how the prion-like tau propagation has been extended from Alzheimer's disease to tauopathies. First, in Alzheimer’s disease, the progression of tau aggregation follows stereotypical anatomical stages which may be considered as spreading. The mechanisms of the propagation are now subject to intensive and controversial research. It has been shown that tau may be secreted in the interstitial fluid in an active manner as reflected by high and constant concentration of extracellular tau during Alzheimer’s pathology. Animal and cell models have been devised to mimic tau seeding and propagation, and despite their limitations, they have further supported to the prion-like propagation hypothesis. Finally, such new ways of thinking have led to different therapeutic strategies in anti-tau immunotherapy among tauopathies and have stimulated new clinical trials. However, it appears that the prion-like propagation hypothesis mainly relies on data obtained in Alzheimer’s disease. From this review, it appears that further studies are needed (1) to characterize extracellular tau species, (2) to find the right pathological tau species to target, (3) to follow in vivo tau pathology by brain imaging and biomarkers and (4) to interpret current clinical trial results aimed at reducing the progression of these pathologies. Such inputs will be essential to have a comprehensive view of these promising therapeutic strategies in tauopathies." @default.
• W2989455730 created "2019-11-22" @default.
• W2989455730 creator A5001925807 @default.
• W2989455730 creator A5039383646 @default.
• W2989455730 creator A5051134184 @default.
• W2989455730 creator A5052854817 @default.
• W2989455730 creator A5053488997 @default.
• W2989455730 creator A5089454538 @default.
• W2989455730 creator A5090623250 @default.
• W2989455730 date "2019-11-04" @default.
• W2989455730 modified "2023-10-18" @default.
• W2989455730 title "From the prion-like propagation hypothesis to therapeutic strategies of anti-tau immunotherapy" @default.
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