FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2989462885> ?p ?o ?g. }

• W2989462885 endingPage "1415" @default.
• W2989462885 startingPage "1401" @default.
• W2989462885 abstract "Abstract Context Individuals with cystic fibrosis (CF) develop a distinct form of diabetes characterized by β-cell dysfunction and islet amyloid accumulation similar to type 2 diabetes (T2D), but generally have normal insulin sensitivity. CF-related diabetes (CFRD) risk is determined by both CFTR, the gene responsible for CF, and other genetic variants. Objective To identify genetic modifiers of CFRD and determine the genetic overlap with other types of diabetes. Design and Patients A genome-wide association study was conducted for CFRD onset on 5740 individuals with CF. Weighted polygenic risk scores (PRSs) for type 1 diabetes (T1D), T2D, and diabetes endophenotypes were tested for association with CFRD. Results Genome-wide significance was obtained for variants at a novel locus (PTMA) and 2 known CFRD genetic modifiers (TCF7L2 and SLC26A9). PTMA and SLC26A9 variants were CF-specific; TCF7L2 variants also associated with T2D. CFRD was strongly associated with PRSs for T2D, insulin secretion, postchallenge glucose concentration, and fasting plasma glucose, and less strongly with T1D PRSs. CFRD was inconsistently associated with PRSs for insulin sensitivity and was not associated with a PRS for islet autoimmunity. A CFRD PRS comprising variants selected from these PRSs (with a false discovery rate &lt; 0.1) and the genome-wide significant variants was associated with CFRD in a replication population. Conclusions CFRD and T2D have more etiologic and mechanistic overlap than previously known, aligning along pathways involving β-cell function rather than insulin sensitivity. Two CFRD risk loci are unrelated to T2D and may affect multiple aspects of CF. An 18-variant PRS stratifies risk of CFRD in an independent population." @default.
• W2989462885 created "2019-11-22" @default.
• W2989462885 creator A5001025455 @default.
• W2989462885 creator A5007768330 @default.
• W2989462885 creator A5007892182 @default.
• W2989462885 creator A5008426210 @default.
• W2989462885 creator A5008461314 @default.
• W2989462885 creator A5008986433 @default.
• W2989462885 creator A5027270754 @default.
• W2989462885 creator A5029360035 @default.
• W2989462885 creator A5038242998 @default.
• W2989462885 creator A5041161022 @default.
• W2989462885 creator A5043283805 @default.
• W2989462885 creator A5047980646 @default.
• W2989462885 creator A5055982974 @default.
• W2989462885 creator A5066829790 @default.
• W2989462885 creator A5067181391 @default.
• W2989462885 creator A5076939812 @default.
• W2989462885 date "2019-10-19" @default.
• W2989462885 modified "2023-10-12" @default.
• W2989462885 title "Genetic Modifiers of Cystic Fibrosis-Related Diabetes Have Extensive Overlap With Type 2 Diabetes and Related Traits" @default.
• W2989462885 cites W1965141016 @default.
• W2989462885 cites W1982898486 @default.
• W2989462885 cites W2005421391 @default.
• W2989462885 cites W2008145349 @default.
• W2989462885 cites W2014679781 @default.
• W2989462885 cites W2024108088 @default.
• W2989462885 cites W2034348332 @default.
• W2989462885 cites W2036275580 @default.
• W2989462885 cites W2069045404 @default.
• W2989462885 cites W2073312634 @default.
• W2989462885 cites W2075327064 @default.
• W2989462885 cites W2077955816 @default.
• W2989462885 cites W2081119435 @default.
• W2989462885 cites W2082793267 @default.
• W2989462885 cites W2091974182 @default.
• W2989462885 cites W2093362931 @default.
• W2989462885 cites W2093619451 @default.
• W2989462885 cites W2106689948 @default.
• W2989462885 cites W2110048796 @default.
• W2989462885 cites W2111078457 @default.
• W2989462885 cites W2111187716 @default.
• W2989462885 cites W2111824788 @default.
• W2989462885 cites W2114854928 @default.
• W2989462885 cites W2115441215 @default.
• W2989462885 cites W2118671703 @default.
• W2989462885 cites W2126237420 @default.
• W2989462885 cites W2131328125 @default.
• W2989462885 cites W2136989779 @default.
• W2989462885 cites W2141770478 @default.
• W2989462885 cites W2145394445 @default.
• W2989462885 cites W2153860431 @default.
• W2989462885 cites W2157752701 @default.
• W2989462885 cites W2159422401 @default.
• W2989462885 cites W2161556085 @default.
• W2989462885 cites W2167412015 @default.
• W2989462885 cites W2167789521 @default.
• W2989462885 cites W2170541981 @default.
• W2989462885 cites W2177538943 @default.
• W2989462885 cites W2179026698 @default.
• W2989462885 cites W2188035077 @default.
• W2989462885 cites W2195783463 @default.
• W2989462885 cites W2262187954 @default.
• W2989462885 cites W2311083859 @default.
• W2989462885 cites W2336227533 @default.
• W2989462885 cites W2346526902 @default.
• W2989462885 cites W2474050011 @default.
• W2989462885 cites W2516036129 @default.
• W2989462885 cites W2606486957 @default.
• W2989462885 cites W2617316722 @default.
• W2989462885 cites W2621290111 @default.
• W2989462885 cites W2734033274 @default.
• W2989462885 cites W2781943016 @default.
• W2989462885 cites W2787440289 @default.
• W2989462885 cites W2828109831 @default.
• W2989462885 cites W2894662039 @default.
• W2989462885 cites W2896006385 @default.
• W2989462885 cites W2916086954 @default.
• W2989462885 cites W2977857995 @default.
• W2989462885 doi "https://doi.org/10.1210/clinem/dgz102" @default.
• W2989462885 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7236628" @default.
• W2989462885 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31697830" @default.
• W2989462885 hasPublicationYear "2019" @default.
• W2989462885 type Work @default.
• W2989462885 sameAs 2989462885 @default.
• W2989462885 citedByCount "31" @default.
• W2989462885 countsByYear W29894628852020 @default.
• W2989462885 countsByYear W29894628852021 @default.
• W2989462885 countsByYear W29894628852022 @default.
• W2989462885 countsByYear W29894628852023 @default.
• W2989462885 crossrefType "journal-article" @default.
• W2989462885 hasAuthorship W2989462885A5001025455 @default.
• W2989462885 hasAuthorship W2989462885A5007768330 @default.
• W2989462885 hasAuthorship W2989462885A5007892182 @default.
• W2989462885 hasAuthorship W2989462885A5008426210 @default.
• W2989462885 hasAuthorship W2989462885A5008461314 @default.
• W2989462885 hasAuthorship W2989462885A5008986433 @default.
• W2989462885 hasAuthorship W2989462885A5027270754 @default.

• next