Matches in SemOpenAlex for { <https://semopenalex.org/work/W2989479224> ?p ?o ?g. }
- W2989479224 endingPage "2012" @default.
- W2989479224 startingPage "2000" @default.
- W2989479224 abstract "Acquisition and extinction of learned fear responses utilize conserved but flexible neural circuits. Here we show that acquisition of conditioned freezing behavior is associated with dynamic remodeling of relative excitatory drive from the basolateral amygdala (BLA) away from corticotropin releasing factor-expressing (CRF+) centrolateral amygdala neurons, and toward non-CRF+ (CRF-) and somatostatin-expressing (SOM+) neurons, while fear extinction training remodels this circuit back toward favoring CRF+ neurons. Importantly, BLA activity is required for this experience-dependent remodeling, while directed inhibition of the BLA-centrolateral amygdala circuit impairs both fear memory acquisition and extinction memory retrieval. Additionally, ectopic excitation of CRF+ neurons impairs fear memory acquisition and facilities extinction, whereas CRF+ neuron inhibition impairs extinction memory retrieval, supporting the notion that CRF+ neurons serve to inhibit learned freezing behavior. These data suggest that afferent-specific dynamic remodeling of relative excitatory drive to functionally distinct subcortical neuronal output populations represents an important mechanism underlying experience-dependent modification of behavioral selection." @default.
- W2989479224 created "2019-11-22" @default.
- W2989479224 creator A5011655951 @default.
- W2989479224 creator A5011813883 @default.
- W2989479224 creator A5016281292 @default.
- W2989479224 creator A5050071588 @default.
- W2989479224 creator A5056897352 @default.
- W2989479224 creator A5069201086 @default.
- W2989479224 creator A5072348910 @default.
- W2989479224 creator A5074875737 @default.
- W2989479224 creator A5075212675 @default.
- W2989479224 date "2019-11-11" @default.
- W2989479224 modified "2023-10-15" @default.
- W2989479224 title "Dynamic remodeling of a basolateral-to-central amygdala glutamatergic circuit across fear states" @default.
- W2989479224 cites W1475399421 @default.
- W2989479224 cites W1745700293 @default.
- W2989479224 cites W1899857231 @default.
- W2989479224 cites W1963723820 @default.
- W2989479224 cites W1966403223 @default.
- W2989479224 cites W1968714114 @default.
- W2989479224 cites W1971198199 @default.
- W2989479224 cites W1975032719 @default.
- W2989479224 cites W1981044491 @default.
- W2989479224 cites W1983578249 @default.
- W2989479224 cites W1995087873 @default.
- W2989479224 cites W2003870213 @default.
- W2989479224 cites W2022611329 @default.
- W2989479224 cites W2026380076 @default.
- W2989479224 cites W2026836897 @default.
- W2989479224 cites W2029988864 @default.
- W2989479224 cites W2042479971 @default.
- W2989479224 cites W2044686824 @default.
- W2989479224 cites W2060978874 @default.
- W2989479224 cites W2064896421 @default.
- W2989479224 cites W2069072617 @default.
- W2989479224 cites W2071699651 @default.
- W2989479224 cites W2075336613 @default.
- W2989479224 cites W2079935199 @default.
- W2989479224 cites W2117117750 @default.
- W2989479224 cites W2125252313 @default.
- W2989479224 cites W2132653427 @default.
- W2989479224 cites W2157081213 @default.
- W2989479224 cites W2240767875 @default.
- W2989479224 cites W2289547156 @default.
- W2989479224 cites W2290106507 @default.
- W2989479224 cites W2342818658 @default.
- W2989479224 cites W2404478434 @default.
- W2989479224 cites W2415217866 @default.
- W2989479224 cites W2427840519 @default.
- W2989479224 cites W2527794060 @default.
- W2989479224 cites W2532170155 @default.
- W2989479224 cites W2563744755 @default.
- W2989479224 cites W2578245286 @default.
- W2989479224 cites W2580493263 @default.
- W2989479224 cites W2602799162 @default.
- W2989479224 cites W2607960418 @default.
- W2989479224 cites W2620639795 @default.
- W2989479224 cites W2745223669 @default.
- W2989479224 cites W2767851849 @default.
- W2989479224 cites W2794689995 @default.
- W2989479224 cites W2803781297 @default.
- W2989479224 cites W2896498740 @default.
- W2989479224 cites W2945624084 @default.
- W2989479224 cites W2952096272 @default.
- W2989479224 doi "https://doi.org/10.1038/s41593-019-0528-7" @default.
- W2989479224 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6884697" @default.
- W2989479224 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31712775" @default.
- W2989479224 hasPublicationYear "2019" @default.
- W2989479224 type Work @default.
- W2989479224 sameAs 2989479224 @default.
- W2989479224 citedByCount "41" @default.
- W2989479224 countsByYear W29894792242019 @default.
- W2989479224 countsByYear W29894792242020 @default.
- W2989479224 countsByYear W29894792242021 @default.
- W2989479224 countsByYear W29894792242022 @default.
- W2989479224 countsByYear W29894792242023 @default.
- W2989479224 crossrefType "journal-article" @default.
- W2989479224 hasAuthorship W2989479224A5011655951 @default.
- W2989479224 hasAuthorship W2989479224A5011813883 @default.
- W2989479224 hasAuthorship W2989479224A5016281292 @default.
- W2989479224 hasAuthorship W2989479224A5050071588 @default.
- W2989479224 hasAuthorship W2989479224A5056897352 @default.
- W2989479224 hasAuthorship W2989479224A5069201086 @default.
- W2989479224 hasAuthorship W2989479224A5072348910 @default.
- W2989479224 hasAuthorship W2989479224A5074875737 @default.
- W2989479224 hasAuthorship W2989479224A5075212675 @default.
- W2989479224 hasBestOaLocation W29894792242 @default.
- W2989479224 hasConcept C100798922 @default.
- W2989479224 hasConcept C101991246 @default.
- W2989479224 hasConcept C112592302 @default.
- W2989479224 hasConcept C118403218 @default.
- W2989479224 hasConcept C151730666 @default.
- W2989479224 hasConcept C15744967 @default.
- W2989479224 hasConcept C16837860 @default.
- W2989479224 hasConcept C169760540 @default.
- W2989479224 hasConcept C170493617 @default.
- W2989479224 hasConcept C17077164 @default.
- W2989479224 hasConcept C2778794669 @default.