Matches in SemOpenAlex for { <https://semopenalex.org/work/W2989496623> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2989496623 endingPage "53" @default.
- W2989496623 startingPage "42" @default.
- W2989496623 abstract "Perianal fistulae are either primary (idiopathic) or secondary [commonly associated with Crohn's disease, (CD)]. It is assumed, although not proven, that the pathophysiology differs.To systematically compare the clinical phenotypes, cytokine and phosphoprotein profiles of idiopathic and CD-related perianal fistulae.Sixty-one patients undergoing surgery for perianal fistula were prospectively recruited (48 idiopathic, 13 CD) into a cohort study. Clinical data, including the Perineal Disease Activity Index (PDAI) and EQ-5D-5L were collected. Biopsies of the fistula tract, granulation tissue, internal opening mucosa and rectal mucosa were obtained at surgery. Concentrations of 30 cytokines and 39 phosphoproteins were measured in each biopsy using a magnetic bead multiplexing instrument and a chemiluminescent antibody array respectively. Over 12000 clinical and 23500 laboratory measurements were made.The PDAI was significantly higher (indicating more active disease) in the CD group with a mean difference of 2.40 (95%CI: 0.52-4.28, P = 0.01). Complex pathoanatomy was more prevalent in the CD group, namely more multiple fistulae, supralevator extensions, collections and rectal thickening. The IL-12p70 concentration at the internal opening specimen site was significantly higher (median difference 19.7 pg/mL, 99%CI: 0.2-40.4, P = 0.008) and the IL-1RA/IL-1β ratio was significantly lower in the CD group at the internal opening specimen site (median difference 15.0, 99%CI = 0.4-50.5, P = 0.008). However in the remaining 27 cytokines and all 39 of the phosphoproteins across the four biopsy sites, no significant differences were found between the groups.CD-related perianal fistulae are more clinically severe and anatomically complex than idiopathic perianal fistulae. However, overall there are no major differences in cytokine and phosphoprotein profiles." @default.
- W2989496623 created "2019-11-22" @default.
- W2989496623 creator A5046012946 @default.
- W2989496623 creator A5050676375 @default.
- W2989496623 creator A5072989992 @default.
- W2989496623 creator A5077905641 @default.
- W2989496623 date "2019-11-13" @default.
- W2989496623 modified "2023-10-12" @default.
- W2989496623 title "Comparison of cytokine and phosphoprotein profiles in idiopathic and Crohn’s disease-related perianal fistula" @default.
- W2989496623 cites W1974242686 @default.
- W2989496623 cites W1977926034 @default.
- W2989496623 cites W1990166011 @default.
- W2989496623 cites W1996662035 @default.
- W2989496623 cites W1997638368 @default.
- W2989496623 cites W2009219530 @default.
- W2989496623 cites W2015479125 @default.
- W2989496623 cites W2030912399 @default.
- W2989496623 cites W2037730752 @default.
- W2989496623 cites W2050353762 @default.
- W2989496623 cites W2063134159 @default.
- W2989496623 cites W2068098802 @default.
- W2989496623 cites W2078900632 @default.
- W2989496623 cites W2089734105 @default.
- W2989496623 cites W2091389437 @default.
- W2989496623 cites W2120232742 @default.
- W2989496623 cites W2136976917 @default.
- W2989496623 cites W2147240986 @default.
- W2989496623 cites W2237934554 @default.
- W2989496623 cites W2326330820 @default.
- W2989496623 cites W2408357249 @default.
- W2989496623 cites W2418611967 @default.
- W2989496623 cites W2579757957 @default.
- W2989496623 cites W2786087266 @default.
- W2989496623 cites W2945424849 @default.
- W2989496623 cites W3022423927 @default.
- W2989496623 cites W31409413 @default.
- W2989496623 cites W4251237509 @default.
- W2989496623 doi "https://doi.org/10.4291/wjgp.v10.i4.42" @default.
- W2989496623 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6854389" @default.
- W2989496623 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31750007" @default.
- W2989496623 hasPublicationYear "2019" @default.
- W2989496623 type Work @default.
- W2989496623 sameAs 2989496623 @default.
- W2989496623 citedByCount "12" @default.
- W2989496623 countsByYear W29894966232021 @default.
- W2989496623 countsByYear W29894966232022 @default.
- W2989496623 countsByYear W29894966232023 @default.
- W2989496623 crossrefType "journal-article" @default.
- W2989496623 hasAuthorship W2989496623A5046012946 @default.
- W2989496623 hasAuthorship W2989496623A5050676375 @default.
- W2989496623 hasAuthorship W2989496623A5072989992 @default.
- W2989496623 hasAuthorship W2989496623A5077905641 @default.
- W2989496623 hasBestOaLocation W29894966231 @default.
- W2989496623 hasConcept C126322002 @default.
- W2989496623 hasConcept C141071460 @default.
- W2989496623 hasConcept C142724271 @default.
- W2989496623 hasConcept C2775934546 @default.
- W2989496623 hasConcept C2776341189 @default.
- W2989496623 hasConcept C2778690821 @default.
- W2989496623 hasConcept C2779134260 @default.
- W2989496623 hasConcept C2779280984 @default.
- W2989496623 hasConcept C71924100 @default.
- W2989496623 hasConcept C90924648 @default.
- W2989496623 hasConceptScore W2989496623C126322002 @default.
- W2989496623 hasConceptScore W2989496623C141071460 @default.
- W2989496623 hasConceptScore W2989496623C142724271 @default.
- W2989496623 hasConceptScore W2989496623C2775934546 @default.
- W2989496623 hasConceptScore W2989496623C2776341189 @default.
- W2989496623 hasConceptScore W2989496623C2778690821 @default.
- W2989496623 hasConceptScore W2989496623C2779134260 @default.
- W2989496623 hasConceptScore W2989496623C2779280984 @default.
- W2989496623 hasConceptScore W2989496623C71924100 @default.
- W2989496623 hasConceptScore W2989496623C90924648 @default.
- W2989496623 hasIssue "4" @default.
- W2989496623 hasLocation W29894966231 @default.
- W2989496623 hasLocation W29894966232 @default.
- W2989496623 hasLocation W29894966233 @default.
- W2989496623 hasLocation W29894966234 @default.
- W2989496623 hasLocation W29894966235 @default.
- W2989496623 hasOpenAccess W2989496623 @default.
- W2989496623 hasPrimaryLocation W29894966231 @default.
- W2989496623 hasRelatedWork W1976676963 @default.
- W2989496623 hasRelatedWork W2036346027 @default.
- W2989496623 hasRelatedWork W2086631895 @default.
- W2989496623 hasRelatedWork W2092186090 @default.
- W2989496623 hasRelatedWork W2385233825 @default.
- W2989496623 hasRelatedWork W2480951826 @default.
- W2989496623 hasRelatedWork W3144185637 @default.
- W2989496623 hasRelatedWork W431915281 @default.
- W2989496623 hasRelatedWork W4319331895 @default.
- W2989496623 hasRelatedWork W4383420693 @default.
- W2989496623 hasVolume "10" @default.
- W2989496623 isParatext "false" @default.
- W2989496623 isRetracted "false" @default.
- W2989496623 magId "2989496623" @default.
- W2989496623 workType "article" @default.