FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2989590061> ?p ?o ?g. }

• W2989590061 endingPage "20" @default.
• W2989590061 startingPage "10" @default.
• W2989590061 abstract "Plants have been suggested as safest source of therapeutic agents, with multi targeted mode of action and least side effects. Tinospora cordifolia, commonly known as Guduchi in India, is one of the most highly valued herbs in Ayurvedic medicine. It possesses potential anti-cancer, anti-inflammatory, hepatoprotective, anti-diabetic, immune-stimulatory and various other beneficial activities.The present study was aimed to investigate the differentiation inducing potential of chloroform and hexane extracts of T. cordifolia using U87MG glioblastoma and IMR-32 neuroblastoma cell lines as model system.Chloroform (Chl-TCE) and hexane (Hex-TCE) extracts significantly reduced the rate of proliferation and induced cell differentiation as evidenced by MTT assay and immunostaining for GFAP and MAP-2 in glioblastoma and neuroblastoma, respectively. Further these extracts increased the expression of stress markers HSP70 and Mortalin and induced senescence. Chloroform and hexane extracts also inhibited the migration of U87MG glioblastoma and IMR-32 neuroblastoma as indicated by wound scratch assay and supported by reduced expression of NCAM. Furthermore these extracts are not toxic to normal cells as they showed no inhibitory effects on primary astrocytic and neuronal cultures.The present study suggests that chloroform and hexane extracts of T. cordifolia retard the rate of proliferation, induce differentiation and inhibit migration of human glioblastomas and neuroblastomas, thus may act as potential phytotherapeutic intervention in treatment of neural cancers." @default.
• W2989590061 created "2019-12-05" @default.
• W2989590061 creator A5015993199 @default.
• W2989590061 creator A5031280653 @default.
• W2989590061 creator A5037176827 @default.
• W2989590061 creator A5053386992 @default.
• W2989590061 date "2019-01-01" @default.
• W2989590061 modified "2023-10-18" @default.
• W2989590061 title "Anti-brain cancer activity of chloroform and hexane extracts of Tinospora cordifolia Miers: an in vitro perspective" @default.
• W2989590061 cites W1113474890 @default.
• W2989590061 cites W1510884166 @default.
• W2989590061 cites W1556366161 @default.
• W2989590061 cites W1942026987 @default.
• W2989590061 cites W1997191870 @default.
• W2989590061 cites W2019130962 @default.
• W2989590061 cites W2020861203 @default.
• W2989590061 cites W2021372785 @default.
• W2989590061 cites W2037813087 @default.
• W2989590061 cites W2044007342 @default.
• W2989590061 cites W2044197183 @default.
• W2989590061 cites W2049908093 @default.
• W2989590061 cites W2050339595 @default.
• W2989590061 cites W2051669288 @default.
• W2989590061 cites W2053861261 @default.
• W2989590061 cites W2069231954 @default.
• W2989590061 cites W2069560599 @default.
• W2989590061 cites W2075221201 @default.
• W2989590061 cites W2076439643 @default.
• W2989590061 cites W2093567435 @default.
• W2989590061 cites W2098466711 @default.
• W2989590061 cites W2100592123 @default.
• W2989590061 cites W2101941700 @default.
• W2989590061 cites W2103695091 @default.
• W2989590061 cites W2110225954 @default.
• W2989590061 cites W2110962672 @default.
• W2989590061 cites W2136841881 @default.
• W2989590061 cites W2150696586 @default.
• W2989590061 cites W2151768480 @default.
• W2989590061 cites W2170551379 @default.
• W2989590061 cites W2171918265 @default.
• W2989590061 cites W2339325236 @default.
• W2989590061 cites W2517465628 @default.
• W2989590061 cites W2728621008 @default.
• W2989590061 cites W2803401818 @default.
• W2989590061 cites W2895548446 @default.
• W2989590061 cites W56999605 @default.
• W2989590061 doi "https://doi.org/10.5214/ans.0972.7531.260104" @default.
• W2989590061 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6894632" @default.
• W2989590061 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31975767" @default.
• W2989590061 hasPublicationYear "2019" @default.
• W2989590061 type Work @default.
• W2989590061 sameAs 2989590061 @default.
• W2989590061 citedByCount "13" @default.
• W2989590061 countsByYear W29895900612020 @default.
• W2989590061 countsByYear W29895900612021 @default.
• W2989590061 countsByYear W29895900612022 @default.
• W2989590061 countsByYear W29895900612023 @default.
• W2989590061 crossrefType "journal-article" @default.
• W2989590061 hasAuthorship W2989590061A5015993199 @default.
• W2989590061 hasAuthorship W2989590061A5031280653 @default.
• W2989590061 hasAuthorship W2989590061A5037176827 @default.
• W2989590061 hasAuthorship W2989590061A5053386992 @default.
• W2989590061 hasBestOaLocation W29895900611 @default.
• W2989590061 hasConcept C185592680 @default.
• W2989590061 hasConcept C202751555 @default.
• W2989590061 hasConcept C2776715637 @default.
• W2989590061 hasConcept C2778523797 @default.
• W2989590061 hasConcept C2780783641 @default.
• W2989590061 hasConcept C2781144210 @default.
• W2989590061 hasConcept C43617362 @default.
• W2989590061 hasConcept C502942594 @default.
• W2989590061 hasConcept C54355233 @default.
• W2989590061 hasConcept C55493867 @default.
• W2989590061 hasConcept C556039675 @default.
• W2989590061 hasConcept C71924100 @default.
• W2989590061 hasConcept C81885089 @default.
• W2989590061 hasConcept C86803240 @default.
• W2989590061 hasConcept C98274493 @default.
• W2989590061 hasConceptScore W2989590061C185592680 @default.
• W2989590061 hasConceptScore W2989590061C202751555 @default.
• W2989590061 hasConceptScore W2989590061C2776715637 @default.
• W2989590061 hasConceptScore W2989590061C2778523797 @default.
• W2989590061 hasConceptScore W2989590061C2780783641 @default.
• W2989590061 hasConceptScore W2989590061C2781144210 @default.
• W2989590061 hasConceptScore W2989590061C43617362 @default.
• W2989590061 hasConceptScore W2989590061C502942594 @default.
• W2989590061 hasConceptScore W2989590061C54355233 @default.
• W2989590061 hasConceptScore W2989590061C55493867 @default.
• W2989590061 hasConceptScore W2989590061C556039675 @default.
• W2989590061 hasConceptScore W2989590061C71924100 @default.
• W2989590061 hasConceptScore W2989590061C81885089 @default.
• W2989590061 hasConceptScore W2989590061C86803240 @default.
• W2989590061 hasConceptScore W2989590061C98274493 @default.
• W2989590061 hasIssue "1" @default.
• W2989590061 hasLocation W29895900611 @default.
• W2989590061 hasLocation W29895900612 @default.
• W2989590061 hasLocation W29895900613 @default.
• W2989590061 hasLocation W29895900614 @default.

• next