Matches in SemOpenAlex for { <https://semopenalex.org/work/W2989595507> ?p ?o ?g. }
- W2989595507 endingPage "4253" @default.
- W2989595507 startingPage "4253" @default.
- W2989595507 abstract "Impaired glutathione (GSH) synthesis and dopaminergic transmission are important factors in the pathophysiology of schizophrenia. Our research aimed to assess the effects of l-buthionine-(S,R)-sulfoximine (BSO), a GSH synthesis inhibitor, and GBR 12909, a dopamine reuptake inhibitor, administered alone or in combination, to Sprague–Dawley rats during early postnatal development (p5–p16), on the levels of GSH, sulfur amino acids, global DNA methylation, and schizophrenia-like behavior. GSH, methionine (Met), homocysteine (Hcy), and cysteine (Cys) contents were determined in the liver, kidney, and in the prefrontal cortex (PFC) and hippocampus (HIP) of 16-day-old rats. DNA methylation in the PFC and HIP and schizophrenia-like behavior were assessed in adulthood (p90–p93). BSO caused the tissue-dependent decreases in GSH content and alterations in Met, Hcy, and Cys levels in the peripheral tissues and in the PFC and HIP. The changes in these parameters were accompanied by alterations in the global DNA methylation in the studied brain structures. Parallel to changes in the global DNA methylation, deficits in the social behaviors and cognitive functions were observed in adulthood. Only BSO + GBR 12909-treated rats exhibited behavioral alterations resembling positive symptoms in schizophrenia patients. Our results suggest the usefulness of this neurodevelopmental model for research on the pathomechanism of schizophrenia." @default.
- W2989595507 created "2019-12-05" @default.
- W2989595507 creator A5004719529 @default.
- W2989595507 creator A5021115653 @default.
- W2989595507 creator A5035122641 @default.
- W2989595507 creator A5035946570 @default.
- W2989595507 creator A5037600955 @default.
- W2989595507 creator A5048770454 @default.
- W2989595507 creator A5050350310 @default.
- W2989595507 creator A5074340792 @default.
- W2989595507 creator A5077951787 @default.
- W2989595507 creator A5082801715 @default.
- W2989595507 date "2019-11-22" @default.
- W2989595507 modified "2023-09-30" @default.
- W2989595507 title "Glutathione Deficiency and Alterations in the Sulfur Amino Acid Homeostasis during Early Postnatal Development as Potential Triggering Factors for Schizophrenia-Like Behavior in Adult Rats" @default.
- W2989595507 cites W147465252 @default.
- W2989595507 cites W1533219519 @default.
- W2989595507 cites W1549590649 @default.
- W2989595507 cites W1938972653 @default.
- W2989595507 cites W1955897922 @default.
- W2989595507 cites W1963479676 @default.
- W2989595507 cites W1965581860 @default.
- W2989595507 cites W1965707086 @default.
- W2989595507 cites W1970240791 @default.
- W2989595507 cites W1970292153 @default.
- W2989595507 cites W1971334707 @default.
- W2989595507 cites W1974849634 @default.
- W2989595507 cites W1978876811 @default.
- W2989595507 cites W1978895733 @default.
- W2989595507 cites W1979121076 @default.
- W2989595507 cites W1983191290 @default.
- W2989595507 cites W1984132673 @default.
- W2989595507 cites W1988732691 @default.
- W2989595507 cites W1992186082 @default.
- W2989595507 cites W1992625977 @default.
- W2989595507 cites W1995739884 @default.
- W2989595507 cites W1996517171 @default.
- W2989595507 cites W1997866877 @default.
- W2989595507 cites W1998115852 @default.
- W2989595507 cites W1999478182 @default.
- W2989595507 cites W2000087607 @default.
- W2989595507 cites W2002480005 @default.
- W2989595507 cites W2004740124 @default.
- W2989595507 cites W2010207380 @default.
- W2989595507 cites W2010537235 @default.
- W2989595507 cites W2010724535 @default.
- W2989595507 cites W2010866173 @default.
- W2989595507 cites W2010911467 @default.
- W2989595507 cites W2011868492 @default.
- W2989595507 cites W2012759191 @default.
- W2989595507 cites W2016267604 @default.
- W2989595507 cites W2018419725 @default.
- W2989595507 cites W2019308992 @default.
- W2989595507 cites W2020902432 @default.
- W2989595507 cites W2021374816 @default.
- W2989595507 cites W2022782092 @default.
- W2989595507 cites W2028994155 @default.
- W2989595507 cites W2029713109 @default.
- W2989595507 cites W2031379951 @default.
- W2989595507 cites W2033616412 @default.
- W2989595507 cites W2034505327 @default.
- W2989595507 cites W2034845317 @default.
- W2989595507 cites W2035477056 @default.
- W2989595507 cites W2039366241 @default.
- W2989595507 cites W2039635263 @default.
- W2989595507 cites W2043523067 @default.
- W2989595507 cites W2043952421 @default.
- W2989595507 cites W2048168782 @default.
- W2989595507 cites W2053099858 @default.
- W2989595507 cites W2054546586 @default.
- W2989595507 cites W2057725227 @default.
- W2989595507 cites W2062573156 @default.
- W2989595507 cites W2063765492 @default.
- W2989595507 cites W2067929856 @default.
- W2989595507 cites W2068181401 @default.
- W2989595507 cites W2074278966 @default.
- W2989595507 cites W2075202804 @default.
- W2989595507 cites W2077595708 @default.
- W2989595507 cites W2080049485 @default.
- W2989595507 cites W2083160251 @default.
- W2989595507 cites W2084535750 @default.
- W2989595507 cites W2085056911 @default.
- W2989595507 cites W2085998059 @default.
- W2989595507 cites W2087302485 @default.
- W2989595507 cites W2087389434 @default.
- W2989595507 cites W2088215062 @default.
- W2989595507 cites W2095574453 @default.
- W2989595507 cites W2103127225 @default.
- W2989595507 cites W2105527159 @default.
- W2989595507 cites W2106785071 @default.
- W2989595507 cites W2111271753 @default.
- W2989595507 cites W2112572641 @default.
- W2989595507 cites W2117633779 @default.
- W2989595507 cites W2122325434 @default.
- W2989595507 cites W2127620446 @default.
- W2989595507 cites W2131721815 @default.
- W2989595507 cites W2140418591 @default.
- W2989595507 cites W2143373379 @default.