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- W2989609623 endingPage "117825" @default.
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- W2989609623 abstract "Hypochlorous/hypochlorite (HClO/ClO−), one of the most important signal molecule, plays a crucial role in many cellular signaling pathways. It is reported that the HClO/ClO− level in mitochondria is important to maintain the normal mitochondrial function. Herein, we present two simple fluorescent probes BAC and mitochondria-targeting fluorescent probe TACB for the detection of ClO−. Probes BAC & TACB could be sensitively and selectivity detecting ClO− at the nanomolar levels with the detection limit of 1.64 × 10−9 M and 9.86 × 10−8 M, respectively. Additionally, probes BAC & TACB with the response unit of CO moiety could selectively detect ClO− over other various analytes such as anions, metal ions and OH, 1O2, H2O2. The response time of probe TACB for ClO− (<20 s), implying that it could offer a real-time analytical assay of ClO−. Finally, probe BAC was used for monitoring the ClO− in HEK293T cells and probe TACB could be utilized to track the fluctuations of exogenous ClO− levels in the mitochondria of Hela cells." @default.
- W2989609623 created "2019-12-05" @default.
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- W2989609623 date "2020-03-01" @default.
- W2989609623 modified "2023-09-27" @default.
- W2989609623 title "Mitochondria-targeting turn-on fluorescent probe for HClO detection and imaging in living cells" @default.
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- W2989609623 doi "https://doi.org/10.1016/j.saa.2019.117825" @default.
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